CLINICAL ONCOLOGY RESEARCH CAREER DEVELOPMENT PROGRAM

临床肿瘤学研究职业发展计划

• 批准号: 3088114
• 负责人: ROBERT J MAYER
• 金额: $ 26.01万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-17 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3088114
• 关键词: clinical trials; health science research; human subject; medical education; oncology; physicians; postgraduate education; training

The Dana-Farber Cancer Institute (DFCI) was designated as a comprehensive cancer center by the National Cancer Institute in 1973. It is located in the Harvard Medical School area, adjacent to the Beth Israel Hospital, the Brigham and Women's Hospital, The Children's Hospital, the Joint Center for Radiation Therapy, and the New England Deaconess Hospital as well as the Harvard Medical School campus itself. Active, long-standing training programs in medical, pediatric, radiation, and surgical oncology at the resident and/or fellow level developed at these facilities have as a major goal the creation of an environment which stimulates young physicians to become investigators in some aspect of academic oncology. This effort has been recognized by the awarding of institutional National Research Service Awards by the NCI to the DFCI (Medical and Pediatric Oncology), Brigham and Women's Hospital (surgical Oncology), and the New England Deaconess Hospital (Surgical Oncology). The present proposal requests support for clinically-trained oncologists who have already completed an initial fellowship-training experience in research, to develop patient-related projects under the direct supervision of a faculty mentor with the goal of becoming independent investigators in a cancer-related area. Specifically, this institutional grant will offer senior fellows and junior faculty the opportunity to master the methodology of experimental design and statistical and/or laboratory techniques and to apply this knowledge to the design and implementation of investigative efforts dealing directly with the study and management of cancer patients. The DFCI and its affiliated institutions combine the availability of a wide spectrum of laboratories with high volume and rich diversity of clinical material so as to provide an usually fertile environment for clinical investigation. Training will be provided by designated faculty mentors at the DFCI and/or adjacent institutions as well as through regularly scheduled lectures, clinical and research conferences, journal clubs, and - where appropriate - formal courses. The overall project will be governed by the Principal Investigator and a 15-member Advisory Committee which will be responsible for selecting physicians to be supported by this grant, assigning faculty members, and approving and periodically evaluating each clinical project. All members of the Advisory Committee as well as all mentors hold faculty appointments at Harvard University and participate in classroom presentations and laboratory and clinical research training. In addition to offering training support through this institutional grant, these faculty members also participate in pre- and post-doctoral training programs at Harvard University through their departmental faculty appointments, either at the DFCI or at neighboring Harvard-affiliated hospitals. It is expected that at the conclusion of a 3-5 year period of support, individuals who have participated in this program will have a mature understanding of a major area of fundamental tumor biology and will have been guided to develop hypotheses, based on this knowledge, which will be examined through the design and implementation of appropriate clinical trials. Through this experience and the publications which such research will generate, these individuals should be able to establish themselves as independent clinical investigators, ready to assume supervisory faculty positions in academic oncology departments.

丹娜-法伯癌症研究所（DFCI）被指定为 1973年，美国国家癌症研究所成立了一个综合性癌症中心。它 位于哈佛医学院区，毗邻贝丝 以色列医院、布里格姆妇女医院、儿童医院 医院、联合放射治疗中心和新英格兰 女执事医院以及哈佛医学院校园本身。 积极的，长期的培训计划，在医疗，儿科， 放射学和外科肿瘤学在居民和/或研究员水平 在这些设施中开发的主要目标是创建一个 鼓励年轻医生成为研究者的环境 学术肿瘤学的某些方面这一努力得到了 由NCI颁发的机构国家研究服务奖， DFCI（医学和儿科肿瘤学），布里格姆妇女医院 （外科肿瘤学）和新英格兰女执事医院（外科 肿瘤学）。目前的建议要求支持临床培训 已经完成初步奖学金培训的肿瘤学家 在研究方面的经验，根据 直接监督教师导师的目标是成为 癌症相关领域的独立研究者。具体地说，这 机构赠款将提供高级研究员和初级教师， 掌握实验设计方法的机会， 统计和/或实验室技术，并将这些知识应用于 设计和实施直接涉及 癌症患者的研究和管理。DFCI及其 附属机构联合收割机提供广泛的 实验室拥有大量和丰富多样的临床材料， 以便为临床研究提供通常肥沃的环境。 培训将由DFCI指定的教师导师提供 和/或邻近的机构，以及通过定期安排 讲座，临床和研究会议，期刊俱乐部，以及-在哪里 适当-正式课程。整个项目将由 首席调查员和一个由15名成员组成的咨询委员会， 负责选择由该补助金支持的医生， 分配教职员工，批准和定期评估 每个临床项目咨询委员会全体成员以及 所有导师都在哈佛大学任教， 参加课堂演示和实验室和临床 研究训练。除了提供培训支持外， 这些教师还参加了预科和 哈佛大学的博士后培训项目， 部门教师的任命，无论是在DFCI或在邻近的 哈佛附属医院预计在一次会议结束时， 3-5年期间的支持，个人谁参加了这一 计划将有一个基本的主要领域的成熟的理解 肿瘤生物学，并将被引导发展假设，基于 这些知识，将通过设计和 开展适当的临床试验。通过这次经历 以及这些研究将产生的出版物， 个人应该能够确立自己的独立性 临床研究者，准备承担监督教师的职位， 学术肿瘤部门。