CLINICAL ONCOLOGY RESEARCH CAREER DEVELOPMENT PROGRAM

临床肿瘤学研究职业发展计划

• 批准号: 2084383
• 负责人: ROBERT J MAYER
• 金额: $ 24.3万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-17 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2084383
• 关键词: clinical trials; health science research; human subject; medical education; oncology; physicians; postgraduate education; training

The Dana-Farber Cancer Institute (DFCI) was designated as a comprehensive cancer center by the National Cancer Institute in 1973. It is located in the Harvard Medical School area, adjacent to the Beth Israel Hospital, the Brigham and Women's Hospital, The Children's Hospital, the Joint Center for Radiation Therapy, and the New England Deaconess Hospital as well as the Harvard Medical School campus itself. Active, long-standing training programs in medical, pediatric, radiation, and surgical oncology at the resident and/or fellow level developed at these facilities have as a major goal the creation of an environment which stimulates young physicians to become investigators in some aspect of academic oncology. This effort has been recognized by the awarding of institutional National Research Service Awards by the NCI to the DFCI (Medical and Pediatric Oncology), Brigham and Women's Hospital (surgical Oncology), and the New England Deaconess Hospital (Surgical Oncology). The present proposal requests support for clinically-trained oncologists who have already completed an initial fellowship-training experience in research, to develop patient-related projects under the direct supervision of a faculty mentor with the goal of becoming independent investigators in a cancer-related area. Specifically, this institutional grant will offer senior fellows and junior faculty the opportunity to master the methodology of experimental design and statistical and/or laboratory techniques and to apply this knowledge to the design and implementation of investigative efforts dealing directly with the study and management of cancer patients. The DFCI and its affiliated institutions combine the availability of a wide spectrum of laboratories with high volume and rich diversity of clinical material so as to provide an usually fertile environment for clinical investigation. Training will be provided by designated faculty mentors at the DFCI and/or adjacent institutions as well as through regularly scheduled lectures, clinical and research conferences, journal clubs, and - where appropriate - formal courses. The overall project will be governed by the Principal Investigator and a 15-member Advisory Committee which will be responsible for selecting physicians to be supported by this grant, assigning faculty members, and approving and periodically evaluating each clinical project. All members of the Advisory Committee as well as all mentors hold faculty appointments at Harvard University and participate in classroom presentations and laboratory and clinical research training. In addition to offering training support through this institutional grant, these faculty members also participate in pre- and post-doctoral training programs at Harvard University through their departmental faculty appointments, either at the DFCI or at neighboring Harvard-affiliated hospitals. It is expected that at the conclusion of a 3-5 year period of support, individuals who have participated in this program will have a mature understanding of a major area of fundamental tumor biology and will have been guided to develop hypotheses, based on this knowledge, which will be examined through the design and implementation of appropriate clinical trials. Through this experience and the publications which such research will generate, these individuals should be able to establish themselves as independent clinical investigators, ready to assume supervisory faculty positions in academic oncology departments.

达纳-法伯癌症研究所(DFCI)被指定为 综合癌症中心于1973年由美国国家癌症研究所主办。它 位于哈佛医学院地区，毗邻贝斯河 以色列医院、布里格姆妇女医院、儿童医院 医院、放射治疗联合中心和新英格兰 女执事医院以及哈佛医学院校园本身。 积极的、长期的医疗、儿科、 住院医师和/或同事一级的放射和外科肿瘤学 在这些设施中开发的一个主要目标是创建 激励年轻医生成为研究人员的环境 学术肿瘤学的某些方面。这一努力已经得到了 NCI颁发机构国家研究服务奖给 布里格姆妇女医院内科和儿科肿瘤学 和新英格兰女执事医院(外科 肿瘤学)。本提案要求支持受过临床培训的 已完成初步团契培训的肿瘤学家 在研究方面的经验，在 对教师导师的直接监督，目标是成为 癌症相关领域的独立调查人员。具体地说，这 院校助学金将为高级研究员和初级教员提供 有机会掌握实验设计的方法学和 统计和/或实验室技术，并将这一知识应用于 侦查工作直接打交道的设计与实现 与癌症患者的研究和管理。DFCI及其ITS 附属机构将广泛的可获得性 实验室数量大，临床材料丰富，因此 为临床研究提供了一个通常肥沃的环境。 培训将由DFCI指定的教员导师提供 和/或邻近机构以及通过定期安排的 讲座，临床和研究会议，杂志俱乐部，以及-在哪里 适当的-正规课程。整个项目将由以下人员管理 首席调查员和一个由15名成员组成的咨询委员会 负责遴选本基金资助的医生， 分配教员，批准和定期评估 每个临床项目。咨询委员会所有成员以及 所有导师都在哈佛大学担任教职，并 参与课堂演示以及实验室和临床 研究训练。除了通过以下方式提供培训支持外 机构资助，这些教职员工还参加预科和 哈佛大学的博士后培训计划 DFCI或邻近的院系教职员工任命 哈佛附属医院。预计在一年结束时 3-5年的支持期，参与此活动的个人 计划将对一个主要的基本领域有一个成熟的理解 肿瘤生物学，并将被指导开发假设，基于 这一知识，将通过设计和 实施适当的临床试验。通过这段经历 而这样的研究将产生的出版物，这些 个人应该能够确立自己的独立性 临床研究人员，准备在#年担任监督教职 学术肿瘤科。