Graduate Training in Cancer Research

简介（由申请人提供）：丹娜-法伯癌症研究所（DFCI）于1973年被美国国家癌症研究所指定为综合性癌症中心。两年后，即1975年，该研究所首次获得机构国家研究服务奖（T32 - CA09172）。从那时起，314人得到了这笔资金的支持（其中75%以上的人仍然担任学术职务），这一资助机制已成为研究所培养临床研究人员能力的重要组成部分。本提案的目的是请求继续支持额外的五年，为希望在学术肿瘤学领域发展的研究生医生提供研究培训。该应用程序的具体目的是为完成医学肿瘤学培训的精选临床医生提供临床、健康服务或实验室调查方面的经验。DFCI提供了广泛的研究环境，为研究项目设计中的思想交流和合作提供了异常丰富的环境。培训将继续通过定期安排的讲座、临床和研究会议以及“湿台”和“干台”实验室活动提供。研究所的研究设施目前包括七座建筑物，总面积为1 165 000平方英尺，供研究所进行调查活动之用。五个独立的部门，包括医学和儿科肿瘤学，癌症生物学，癌症免疫学和艾滋病，以及生物统计科学，提供了广泛的调查机会。该提案支持的学员可以从所有这些实验室中选择他们希望进行研究的领域。研究所的所有工作人员都在哈佛大学担任教职，并参加课堂演讲、实验室和临床研究培训。除了这项机构资助提供的培训支持外，DFCI的研究人员还通过在邻近的哈佛附属医院的院系教员任命，参加哈佛大学的博士前和博士后培训项目。2000年，该研究所的综合癌症中心地位扩大到包括与哈佛医学院、哈佛大学公共卫生学院和附属医院（即Dana- Farber/哈佛癌症中心[DF/HCC]）相关的所有生物医学设施；DF/HCC核心拨款在2000年的首次审查和2005年6月的再次审查中都获得了出色的评级。本提案中所述项目的目标是鼓励学术肿瘤学家的发展，这些肿瘤学家将主要在研究所而不是其他哈佛附属机构进行调查活动。预计在培训结束时，该计划支持的个人将有能力独立或在最少的监督下设计，启动和完成个人研究项目，并很快能够成为独立的研究人员。

DESCRIPTION (provided by applicant): The Dana-Farber Cancer Institute (DFCI) was designated as a comprehensive cancer center by the National Cancer Institute in 1973. Two years later, in 1975, the Institute was initially awarded an institutional National Research Service Award (T32 - CA09172). Since that time, 314 individuals have been supported by this grant (more than 75% of whom remain in academic positions) and this funding mechanism has become an essential component in the ability of the Institute to develop clinical investigators. The purpose of this proposal is to request continued support for an additional five years to provide research training for postgraduate physicians who desire a career in academic oncology. The specific purpose of this application is to offer an experience in clinical, health services, or laboratory investigation to highly selected clinicians who have completed their training in medical oncology. The availability of a wide spectrum of research environments within the DFCI offers an unusually fertile environment for the exchange of ideas and for collaboration in the design of research programs. Training will continue to be provided through regularly scheduled lectures, clinical and research conferences, and both "wet bench" and "dry bench" laboratory activities. The research facilities of the DFCI presently include seven buildings containing 1,165,000 gross square feet for investigative activities now contained within the Institute. Five separate departments including Medical and Pediatric Oncology, Cancer Biology, Cancer Immunology and AIDS, and Biostatistical Science offer a wide panoply of investigative opportunities. Trainees supported by this proposal are able to select from among all of these laboratories as the area in which they wish to conduct their research. All members of the Institute staff hold faculty appointments at Harvard University and participate in classroom presentations and laboratory and clinical research training. In addition to the training support provided by this institutional grant, DFCI investigators also participate in pre- and postdoctoral training programs at Harvard University through their departmental faculty appointments of at neighboring Harvard-affiliated hospitals. In 2000, the Institute's comprehensive cancer center status was expanded to embrace all of the biomedical facilities associated with Harvard Medical School, the Harvard University School of Public Health, and affiliated hospitals (i.e. Dana- Farber/Harvard Cancer Center [DF/HCC]); the DF/HCC core grant received an outstanding rating both at the time of its initial review in 2000 and when reviewed again in June, 2005. The goal of the program described in this proposal is to encourage the development of academic oncologists who will perform their investigative activities primarily based at the Institute as opposed to other Harvard-affiliated facilities. It is expected that at the conclusion of their training, those individuals supported by this program will have the capability for designing, initiating, and completing individual research projects, independently or with minimal supervision, and soon thereafter will be able to establish themselves as independent research investigators. PUBLIC HEALTH RELEVANCE: The Dana-Farber Cancer Institute (DFCI) was designated as a comprehensive cancer center by the National Cancer Institute in 1973, charged with the mission of improving the understanding of the causes of neoplastic disease and enhancing the quality of treatment which can be offered to cancer patients. To accomplish these goals, a large number of investigative laboratories encompassing the entire spectrum of tumor biology and health services research has been established alongside an active clinical oncology program, closely linked with the adjacent facilities of the Harvard Medical School and surrounding affiliated hospitals. The interaction between laboratory-based scientists and clinical investigators has created a uniquely productive environment leading to major advances in fundamental science and the application of these efforts to patient care.