Graduate Training in Cancer Research

描述（由申请人提供）：丹娜-法伯癌症研究所（DFCI）于1973年被国家癌症研究所指定为综合性癌症中心。两年后，在1975年，该研究所最初被授予机构国家研究服务奖（T32 -CA 09172）。从那时起，314个人已经支持了这个补助金（超过75%的人留在学术职位），这种资助机制已成为研究所的能力，以发展临床研究人员的一个重要组成部分。该提案的目的是要求在未来五年内继续支持为希望从事学术肿瘤学职业的研究生医生提供研究培训。此应用程序的具体目的是提供在临床，卫生服务，或实验室研究经验，高度选择的临床医生谁已经完成了在医学或儿科肿瘤学的培训。DFCI内广泛的研究环境的可用性为思想交流和研究计划设计的合作提供了一个异常肥沃的环境。将继续通过定期讲座、临床和研究会议以及“湿台”和“干台”实验室活动提供培训。DFCI的研究设施目前包括七座建筑物，总面积为1，165，000平方英尺，用于研究所内的调查活动。五个独立的部门，包括医学和儿科肿瘤学，癌症生物学，癌症免疫学和艾滋病，以及生物统计科学提供了广泛的调查机会。受这一建议支持的受训者能够从所有这些实验室中选择他们希望进行研究的领域。研究所的所有工作人员都在哈佛大学担任教职，并参加课堂演示、实验室和临床研究培训。除了该机构赠款提供的培训支持外，DFCI研究人员还通过其在邻近哈佛附属医院的部门教师任命参加哈佛大学的博士前和博士后培训计划。2000年，该研究所的综合癌症中心的地位扩大到包括与哈佛医学院、哈佛大学公共卫生学院和附属医院有关的所有生物医学设施（即Dana-Farber/哈佛癌症中心[DF/HCC]）; DF/HCC核心补助金在2000年的初次审查和2005年6月的再次审查中均获得了优秀评级。该计划的目标是鼓励学术肿瘤学家的发展，他们将主要在研究所而不是其他哈佛附属设施进行调查活动。预计在他们的培训结束时，这些个人由该计划支持将有能力设计，启动和完成个人的研究项目，独立或最小的监督，并在此后不久将能够建立自己作为独立的研究调查。

DESCRIPTION (provided by applicant): The Dana-Farber Cancer Institute (DFCI) was designated as a comprehensive cancer center by the National Cancer Institute in 1973. Two years later, in 1975, the Institute was initially awarded an institutional National Research Service Award (T32 -CA09172). Since that time, 314 individuals have been supported by this grant (more than 75% of whom remain in academic positions) and this funding mechanism has become an essential component in the ability of the Institute to develop clinical investigators. The purpose of this proposal is to request continued support for another five years to provide research training for postgraduate physicians who desire a career in academic oncology. The specific purpose of this application is to offer an experience in clinical, health services, or laboratory investigation to highly selected clinicians who have completed their training in medical or pediatric oncology. The availability of a wide spectrum of research environments within the DFCI offers an unusually fertile environment for the exchange of ideas and for collaboration in the design of research programs. Training will continue to be provided through regularly scheduled lectures, clinical and research conferences, and both "wet bench" and "dry bench" laboratory activities. The research facilities of the DFCI presently include seven buildings containing 1,165,000 gross square feet for investigative activities now contained within the Institute. Five separate departments including Medical and Pediatric Oncology, Cancer Biology, Cancer Immunology and AIDS, and Biostatistical Science offer a wide panoply of investigative opportunities. Trainees supported by this proposal are able to select from among all of these laboratories as the area in which they wish to conduct their research. All members of the Institute staff hold faculty appointments at Harvard University and participate in classroom presentations and laboratory and clinical research training. In addition to the training support provided by this institutional grant, DFCI investigators also participate in pre- and postdoctoral training programs at Harvard University through their departmental faculty appointments of at neighboring Harvard-affiliated hospitals. In 2000, the Institute's comprehensive cancer center status was expanded to embrace all of the biomedical facilities associated with Harvard Medical School, the Harvard University School of Public Health, and affiliated hospitals (i.e. Dana-Farber/Harvard Cancer Center [DF/HCC]); the DF/HCC core grant received an outstanding rating both at the time of its initial review in 2000 and when reviewed again in June, 2005. The goal of the program described in this proposal is to encourage the development of academic oncologists who will perform their investigative activities primarily at the Institute as opposed to other Harvard-affiliated facilities. It is expected that at the conclusion of their training, those individuals supported by this program will have the capability for designing, initiating, and completing individual research projects, independently or with minimal supervision, and soon thereafter will be able to establish themselves as independent research investigators.