ESTABLISHMENT OF A BREEDING AND RESEARCH PROGRAM

建立育种和研究计划

• 批准号: 2282831
• 负责人: PATRICE A FROST
• 金额: $ 89.47万
• 依托单位: COULSTON FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-30 至 1995-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2282831
• 关键词: Pan; animal breeding; animal care; animal colony; animal population genetics; automated medical record system; clinical chemistry; computer network; ethology; histopathology; online computer; veterinary medicine

The objective of the study is to house and manage a breeding colony of 117 chimpanzees that will serve as a national resource of animals for biomedical and behavioral research. The specific aims are: Aim 1. To maintain a colony of chimpanzees composed of proven breeders and potential breeders for perpetuation of the colony. Aim 2. To continue the use of the harem breeding system which will provide about 25 pregnancies per year. Aim 3. To maintain the research resource as a stable, self-perpetuating colony by providing excellent animal husbandry, veterinary care, and a new housing facility. Aim 4. To develop an accurate and thorough computer system that will provide high quality long term records of animal health, pedigree, behavior, and research uses. Aim 5. To create a new behavioral biology division that will develop an applied and basic behavioral research program which will support the long-term research goals of the Chimpanzee Breeding and Research Program. The proposed colony has 77 confirmed breeders and 40 potential breeders. A harem system (1 male + 3 females) of breeding will be used to provide genetic diversity, protection against widespread disease transmission, and excellent reproduction. Approximately 50% of the chimpanzees produced will be retained each year to serve as eventual replacement breeders. The ratio will be four females to one male. Infants destined for breeding will be left with their mothers for one year. After weaning, they will be housed in peer groups in large indoor/outdoor housing. A new $10.5 million will be built during the new grant period. The entire National Chimpanzee Breeding Research Program animals will be housed in indoor/outdoor quarters with access to exercise yards. A computer network system that will enable the facility to establish a centralized up to date data base will established for the first time. Behavioral management and studies of the chimpanzee colony will enable PRL to provide programs for psychological enrichment, breeding, sociosexual development, and modifying behaviors of animals in need of rehabilitation following use in biomedical research after their return to PRL. Initially, of significant importance will be the studying of chimpanzees' behavior for group/harem allocation into the new facility.

这项研究的目的是安置和管理一个117只的繁殖群体。 黑猩猩将成为国家的动物资源， 生物医学和行为研究。 具体目标是：目标1。到 维持一个黑猩猩群体， 繁殖者以使殖民地永久化。 目标2.继续使用 每年将提供约25次怀孕的后宫繁殖系统。 目标3。保持研究资源的稳定，自我延续 殖民地提供优良的畜牧业，兽医护理，和一个新的 住房设施。 目标4。开发一个精确而全面的计算机 系统将提供高质量的长期动物健康记录， 血统行为和研究用途 目标5。创造新的行为 生物学部门将开发一个应用和基础行为研究 该计划将支持黑猩猩的长期研究目标 育种和研究计划。 拟议的殖民地有77个确认的育种和40个潜在的育种。 一个繁殖的后宫系统（1只雄性+3只雌性）将用于提供 遗传多样性，防止疾病传播， 很好的复制。 大约50%的黑猩猩会 每年都被保留作为最终的替代育种者。 之比 将是四雌一雄注定要生育的婴儿将 和母亲一起生活了一年。 断奶后，它们将被安置在 在大型室内/室外住房的同龄人群体中。 在新的赠款期内将建造一个新的1 050万美元的项目。 整个 国家黑猩猩育种研究计划的动物将被安置在 可通往运动场的室内/室外宿舍。 一个计算机网络系统，使该设施能够建立一个 第一次建立集中的最新数据库。 对黑猩猩群体的行为管理和研究将使PRL 提供心理充实，繁殖，社会性 需要康复的动物的发展和改变行为 返回PRL后用于生物医学研究。 起初， 对黑猩猩行为的研究将具有重要意义， 组/后宫分配到新设施。