MOLECULAR RECOGNITION OF LIPIDS AND LIPOPHILES BY CYCLODEXTRIN DERIVATIVES

环糊精衍生物对脂质和亲脂剂的分子识别

• 批准号: 3745427
• 负责人: J PITHA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3745427
• 关键词: carbohydrate analog; chemical reaction; chemical structure; cyclodextrins; dosage; drug adverse effect; drug delivery systems; drug quality /standard; intermolecular interaction; lipid solubility; lipids; water solubility

Hydroxypropyl cyclodextrins, which originated in this section in 1981, are chemical derivatives of enzymatically modified starch and can be used as powerful solubilizers of non-polar, water insoluble substances. Such solubilization makes it possible to prepare highly effective pharmaceutical formulations directly from hormones and proteins and eliminates the usual need for chemical modification to make them pharmaceutically acceptable. Thus, hydroxypropyl cyclodextrins may be expected to improve therapeutics of chronic diseases of elders, many of which involve hormonal supplementation. The present results of the section's work help delineate the conditions of safe therapy by identifying dosages and styles of uses of hydroxypropyl cyclodextrins.

羟丙基环糊精，它起源于这个 1981年，化学衍生物 酶改性淀粉，可用作强大的 非极性水不溶性物质的增溶剂。 这样的增溶使得可以制备高度分散的聚合物。 有效的药物制剂直接从 激素和蛋白质，并消除了通常需要 化学修饰使其成为药物 可以接受的 因此，羟丙基环糊精可以是 有望改善慢性疾病的治疗方法 老年人，其中许多涉及荷尔蒙补充剂。 该科目前的工作成果有助于说明 安全治疗的条件，通过确定剂量和 羟丙基环糊精的用途。

项目成果

Influence of Supercritical Carbon Dioxide on the Activity and Conformational Changes of α-Amylase, Lipase, and Peroxidase in the Solid State Using White Wheat Flour as an Example.

超临界二氧化碳对固态中α-淀粉酶，脂肪酶和过氧化酶在固态中的活性和构象变化的影响，以白麦粉为例。

• DOI: 10.3390/foods12244499
• 发表时间: 2023-12-16
• 期刊: FOODS
• 影响因子: 5.2
• 作者: Ivanovic, Milena;Knez, Zeljko;Leitgeb, Maja
• 通讯作者: Leitgeb, Maja