MEDICINAL CHEMISTRY APPLIED TO PROBLEMS PROMINENT IN SENESCENCE

药物化学应用于解决衰老中的突出问题

• 批准号: 4687875
• 负责人: J PITHA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4687875
• 关键词: aging; angina pectoris; antiarrhythmic agent; antihypertensive agents; beta antiadrenergic agent; drug adverse effect; drug design /synthesis /production; drug metabolism; drug screening /evaluation; drug vehicle; lipid solubility; neoplasm /cancer pharmacology; nutrition related tag; polysaccharides; vitamin A deficiency; vitamin therapy; water solubility

Two problems which have relevance to aging have been studied. In the field of congeners of catecholamines the following results were obtained: (A) A new series of compounds which selectively destroy beta-adrenoceptors was developed which has indexes about two orders better than previously available compounds. The results suggest that new series will enable selective manipulation of beta-adrenoceptors in brain to be performed in a practical manner. (B) A compound which activates and then attaches itself permanently to beta-adrenoceptors was prepared. Evaluation of this compound indicates that beta-adrenoceptor has intrinsic self-deactivation capacity, i.e. cannot be jammed in activated state. (C) Orientation studies of dopamine confiners were initiated. In the field of solubilizers of lipophilic hormones and drugs the previously developed compounds, hydrophilic derivatives of cyclodextrins, were analyzed thoroughly and prepared in quantity to support two clinical evaluation studies.

本文研究了与衰老有关的两个问题。在野外