环糊精衍生物对脂质和亲脂剂的分子识别-猫眼课题宝

环糊精衍生物对脂质和亲脂剂的分子识别

批准号：

3802188

负责人：

J PITHA

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE ON AGING

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3802188

关键词：

carbohydrate analog chemical reaction chemical synthesis cyclodextrins drug /agent drug delivery systems lipid solubility lipids molecular site pharmacokinetics sedimentation equilibrium water solubility

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英文摘要

Chemical derivatives of carbohydrates, hydroxypropylcyclodextrins, originated in the Section are potent and nontoxic solubilizers of drugs, hormones and of lipids. These solubilizers have many applications in pharmaceutics and pharmacology and presently some preparations based on them are used in man in phase one studies. The work of the section has been focused on (a) optimization of solubilizing abilities of hydroxypropylcyclodextrins through the study of chemical reactivity of cyclodextrins and (b) on easier preparation of solid pharmaceutical formulations through the study of equilibria in the system of hydroxpropylcyclodextrin: drug: solvent.

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