MOLECULAR RECOGNITION OF LIPIDS AND LIPOPHILES BY CYCLODEXTRIN DERIVATIVES

环糊精衍生物对脂质和亲脂剂的分子识别

• 批准号: 3802188
• 负责人: J PITHA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3802188
• 关键词: carbohydrate analog; chemical reaction; chemical synthesis; cyclodextrins; drug /agent; drug delivery systems; lipid solubility; lipids; molecular site; pharmacokinetics; sedimentation equilibrium; water solubility

Chemical derivatives of carbohydrates, hydroxypropylcyclodextrins, originated in the Section are potent and nontoxic solubilizers of drugs, hormones and of lipids. These solubilizers have many applications in pharmaceutics and pharmacology and presently some preparations based on them are used in man in phase one studies. The work of the section has been focused on (a) optimization of solubilizing abilities of hydroxypropylcyclodextrins through the study of chemical reactivity of cyclodextrins and (b) on easier preparation of solid pharmaceutical formulations through the study of equilibria in the system of hydroxpropylcyclodextrin: drug: solvent.

碳水化合物的化学衍生物，羟丙基环糊精， 是药物的有效和无毒的增溶剂， 激素和脂质。 这些增溶剂具有许多应用， 药物学和药理学以及目前一些基于 它们在第一阶段研究中用于人类。 该科的工作 （a）优化的增溶能力， 通过研究羟丙基环糊精的化学反应性， 环糊精和（B）更容易制备固体药物 通过研究系统中的平衡， 羟丙基环糊精：药物：溶剂。