MOLECULAR RECOGNITION OF LIPIDS AND LIPOPHILES BY CYCLODEXTRIN DERIVATIVES

环糊精衍生物对脂质和亲脂剂的分子识别

• 批准号: 3789742
• 负责人: J PITHA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789742
• 关键词: carbohydrate analog; chemical reaction; chemical structure; crystallization; cyclodextrins; drug delivery systems; intermolecular interaction; lipid solubility; lipids; water solubility

Hydroxypropyl Cyclodextrins, chemical derivatives of glucose oligosaccharides, which were originated in the section, form water soluble complexes with lipophiles. Since these derivatives are also non-toxic they have been used as drug solubilizers with enough of success to qualify them for consideration to be included in the next edition of US Pharmacopea/National Formulary. Since hydroxypropyl cyclodextrins are amorphous mixtures of chemical individua and thus difficult to characterize, the present work of the section has been focused on the effects which preparative conditions may have on their properties. The reactivity of cyclodextrins was investigated, the mixtures subjected to a detailed analysis, several components of these and of similar mixtures were isolated as chemical individua, crystallized and their crystal structure determined.

羟丙基环糊精，葡萄糖的化学衍生物 低聚糖，其中起源于部分，形成水溶性 与亲脂体的复合物。 由于这些衍生物也是无毒的 它们已经被用作药物增溶剂， 他们考虑将其列入下一版美国 药典/国家处方集。 由于羟丙基环糊精是 化学个体的无定形混合物，因此难以 该科目前的工作重点是 制备条件对其性能的影响。 的 环糊精的反应性进行了研究，混合物进行了 详细分析，这些和类似混合物的几种成分 以化学个体的形式分离、结晶， 结构确定。