MEDICINAL CHEMISTRY APPLIED TO PROBLEMS PROMINENT IN SENESCENCE

药物化学应用于解决衰老中的突出问题

• 批准号: 3817556
• 负责人: J PITHA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3817556
• 关键词: alpha adrenergic receptor; androgens; antiadrenergic agents; beta adrenergic receptor; beta antiadrenergic agent; chemical binding; drug adverse effect; drug design /synthesis /production; drug metabolism; drug receptors; drug screening /evaluation; drug vehicle; human subject; laboratory rat; lipid solubility; nutrition related tag; peripheral nervous system; prazosin; retinoids; testosterone; water solubility

Amorphous derivatives of cyclodextrins, compounds which (a) combine the advantages of host-guest complexation of drug with the advantages of the conversion of drug into a stable amorphous state, (b) have low toxicity, (c) can be fully characterized, and (d) were developed in the Section, have started to come of age. These compounds are currently produced in several countries and have already been used in one clinical trial.

环糊精的无定形衍生物，化合物（a）结合联合收割机 药物与药物的主客体络合的优点 将药物转化为稳定的无定形状态的优点， (b)具有低毒性，（c）可以充分表征，和（d）是 已经开始成熟了 这些 化合物目前在几个国家生产， 已经在一个临床试验中使用。