HEALTH HAZARDS FROM GROUNDWATER CONTAMINATION

该应用程序申请资金以继续进行生物医学和生态工程 旨在更好地了解潜在健康危害的研究 通常是由于地下水和土壤受到化学品污染而引起的 在危险废物现场发现的。正在调查的污染物包括 挥发性有机溶剂，如苯和三氯乙烯以及 对环境具有持久性的化合物，如多氯联苯和多环芳烃。由23人组成的小组 来自密歇根州立大学、密歇根大学和 普渡大学将参与一项合作和综合研究 项目涉及16个研究项目。浅谈环境污染的修复问题 受污染场地包括生物降解过程的基础研究和 使用化学改性粘土来吸附和催化破坏 污染物的数量。挥发性有机化合物在土壤中的传输 对地下进行了实验研究，并改进了数学模型 对这一运动的描述正在开发中，用于预测 清理前后的环境浓度。 生物医学科学家正在研究这种化合物的毒性机制 选定的一组化学物质。将包括对化学诱导的研究 涉及中性粒细胞、生殖系统的毒性，以及对 细胞间通讯和其他基本的细胞调节 流程。此外，各种生物系统被用来 确定生态工程过程中产生的产品的潜在毒性 细菌和化学降解的研究。一种新的评估系统 将开发多氯联苯和多环芳烃混合物的生物活性 使用基因工程技术。这项研究将产生几个新的、 灵敏的生物检测/生物标志物系统用于检测和监测 卤代芳香烃。 研究工作伴随着一个培训部分，该部分提供 对研究生和博士后研究员进行毒理学教育 在现场修复研究中。

This application requests funds to continue biomedical and ecoengineering research directed toward a better understanding of potential health hazards arising from contamination of groundwater and soils with chemicals commonly found at hazardous waste sites. The pollutants under investigation include volatile organic solvents such as benzene and trichloroethylene and environmentally persistent compounds such as PCBs and PAHs. A group of 23 scientists from Michigan State University, the University of Michigan and Purdue University will engage in a collaborative and integrated research program involving 16 research projects. Research on remediation of contaminated sites includes basic studies of biodegradation processes and the use of chemically modified clays to adsorb and catalyze the destruction of pollutants. The transport of volatile organic compounds in the subsurface is studied experimentally and refined mathematical models describing this movement are being developed for use in predicting environmental concentrations before and after clean-up. Biomedical scientists are examining the mechanisms of toxicity of the same selected group of chemicals. Included will be studies of chemical-induced toxicity involving neutrophils, the reproductive system, and inhibition of intercellular communication and other fundamental cellular regulation processes. In addition, various biological systems are employed to determine the potential toxicity of products produced during ecoengineering studies of bacterial and chemical degradation. A novel system to assess the biological activity of mixtures of PCBs and PAHs will be developed using genetic engineering techniques. The study will produce several new, sensitive bioassay/biomarker systems for detection and monitoring of halogenated aromatic hydrocarbons. The research effort is accompanied by a training component which provides toxicology education to graduate students and postdoctoral fellows involved in site remediation research.