HEALTH HAZARDS FROM GROUNDWATER CONTAMINATION

要求提供支助，继续开展以人类健康为导向的研究，探讨接触超级基金场址中常见的化学品所带来的风险，并探讨新的清理技术，以消除接触这些场址中化学品的可能性。正在调查的污染物包括三氯乙烯等污染地下水的相对水溶性化学品和多氯联苯和多环芳烃等环境持久性脂溶性化学品。提出了一个高度综合的，多学科的研究计划，包括九个研究项目和四个支持核心单元。由24名研究人员组成的研究团队包括9个研究项目和4个支持核心单位的教师。由24名研究人员组成的研究小组包括密歇根州立大学（12名）、密歇根大学（8名）、斯坦福大学（2名）、罗格斯大学（1名）和橡树岭国家实验室（1名）的教师。研究的主要重点是四个领域：1）了解控制污染物的环境持久性和生物可利用性的因素对参与生物降解的微生物的机制，（三）确定故意变更的效力（工程）地下环境对生物降解速率的影响; 4）评价环境中产生的化学产品对生物降解速率的影响;评价生物修复产生的化学产品的潜在毒性，3）测定有目的地改变（工程化的）地下环境对生物降解速率的有效性，和4）评价生物修复产生的化学产品的生物降解速率，和4）评价生物修复产生的化学产品的潜在毒性。被列为生物医学的研究项目包括研究多氯联苯对免疫毒性、生殖和发育毒性以及发育神经毒性的影响，场地补救研究包括地下水污染物的生殖生物补救，合成和开发新的宏量化学品以参与化学品的保留，参与含有卤化溶剂和金属的地下水羽流中的化学品的保留，以及对控制地下水和土壤生物修复速度的因素的检查。一个核心实验室将协调对混合废物中常见的多氯联苯和其他污染物生物降解产生的中间产品和最终产品的测试。这种测试将允许修改实验补救程序，以最大限度地消除环境中发现的有毒混合物的毒性。博士后培训计划将涉及交叉培训经验，以提高新博士的能力。毕业生在多学科研究团队中进行。一个外联核心将与密歇根大学环境保护局有害物质研究中心的社区援助部分合作，制作信息材料，用于与受危险化学品接触威胁影响的社区合作。

Support is requested to continue human health-oriented research on risks from exposure to chemicals commonly found in Superfund sites and on new clean-up technologies to eliminate the potential for exposure to chemicals from thos3e sites. The pollutants under investigation include relatively water soluble chemicals that contaminate groundwater such as trichloroethylene and environmentally persistent lipid soluble chemicals such as PCBs and PAHs. A highly integrated, multi-disciplinary research program is proposed consisting of nine research projects and four supporting core units. The research team of 24 investigators include faculty at nine research projects and four supporting core units. The research team of 24 investigators include faculty at Michigan State University (12), The University of Michigan (8), Stanford (2), Rutgers (1) ant the Oak Ridge National Laboratory (1). The major thrusts of the research are in four areas: 1) understanding the mechanisms of factors controlling the environmental persistence and bioavailability of contaminants to microbes involved in biodegradation, 3) determination of the effectiveness of purposefully altered (engineered) subsurface environments on the rates of biodegradation and 4) evaluation of chemical products produced from environments on the rates of biodegradation and 4) evaluation of chemical products produced from bioremediation for toxicity potential, 3) determination of the effectiveness of purposefully altered (engineered) subsurface environments on the rates of biodegradation and 4) evaluation of chemical products produced from bioremediation on the rate of biodegradation and 4) evaluation of chemical products produced from bioremediation for toxicity potential. The research projects classified as biomedical include studies examining the effects of PCBs to cause immunotoxicity, reproductive and developmental toxicity, and developmental neurotoxicity, Site remediation research includes reproductive bioremediation of groundwater contaminants, the synthesis and development of novel macrochemical to participate in retention of chemicals to participate in retention of chemicals in groundwater plumes containing halogenated solvents and metals, and an examination of factors that control the rate of groundwater and soil bioremediation. A core laboratory will coordinate the testing of the intermediate and end products generated from biodegradation of PCBs and other contaminants commonly found in mixed waste. This testing will permit modification of experimental remediation processes to maximize the detoxification of toxic mixtures found in the environment. A postdoctoral training program will involve cross training experiences to improve the ability of recent Ph.D. graduates to perform in multi-disciplinary research teams. An Outreach Core will partner with the community assistance component of an EPA Hazardous Substance Research Center at the University of Michigan to produce information materials for use in working with communities impacted by the threat of exposure to hazardous chemicals.