CLASSIFICATION OF EARLY ONSET DYSTHYMIA

早发性心境恶劣的分类

• 批准号: 2246760
• 负责人: Daniel N Klein
• 金额: $ 7.53万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2246760
• 关键词: clinical depression; disease /disorder classification; family genetics; genetic disorder diagnosis; human subject; interview; major depression; medical records; mental disorder diagnosis; mood disorders; personality disorders

The relationship between characterological depression, or DSM-III-R primary early-onset dysthymia (PEOD), and the major affective and personality disorders has long been debated. The PI's preliminary work suggests that PEOD is a complex condition with links to both the major mood and personality disorders. The present proposal seeks to extend this work with a clinical and family study of PEOD. Subjects will include 100 outpatients with PEOD, 50 outpatients with episodic major depression (EMD), and 50 normal controls, and their first-degree relatives. Four major questions will be addressed: a. Is PEOD a more severe form of mood disorder than EMD from the standpoint of familial transmission? b. Which personality disorders are more common in PEOD than EMD? c. Other than mood disorders, are there other familial factors which distinguish PEOD from EMD? d. Which of five models of the relationships between PEOD and the major affective and Axis II disorders best explains the pattern of mood and personality disorders in relatives of PEOD, EMD, and normal probands?

性格抑郁症或DSM-III-R原发性 早发性心境恶劣（PEOD），以及主要的情感和人格 长期以来，疾病一直是争论的焦点。 PI的初步工作表明， PEOD是一种复杂的疾病，与主要情绪和 人格障碍 本建议旨在扩大这项工作， PEOD的临床和家庭研究。 受试者将包括100名门诊患者 与PEOD，50例门诊发作性抑郁症（EMD），和50 正常对照组和他们的一级亲属 四大疑问 将处理： a. PEOD是一种比EMD更严重的情绪障碍吗？ 家庭传播的观点？ B. 哪些人格障碍在PEOD中比EMD更常见？ C. 除了情绪障碍还有其他家族因素吗 这 区分PEOD和EMD？ D. 在PEOD与 的 主要情感和轴II障碍最好地解释了 情绪模式 和人格障碍 PEOD、EMD和正常 先证者