Temperamental Low PE in Preschoolers and Depression Risk

学龄前儿童的气质性低体育水平与抑郁风险

• 批准号: 6821558
• 负责人: Daniel N Klein
• 金额: $ 67.57万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6821558
• 关键词: behavioral /social science research tag; case history; child behavior disorders; child mental disorders; clinical research; depression; disease /disorder onset; disease /disorder proneness /risk; electroencephalography; human subject; longitudinal human study; mood disorders; parent offspring interaction; pathologic process; patient oriented research; preschool child (1-5); reinforcer

DESCRIPTION (provided by applicant): Little is known about the precursors and early manifestations of depression. Recent theoretical and empirical work on temperament and mood disorders in adults and children has converged in suggesting that temperamental low positive emotionality (PE) may be a precursor of subsequent depressive disorders. We seek to begin to test this hypothesis by assessing temperament in a large community sample of 3-year old children, examining the relationship between low PE and two better established risk factors for depression, and investigating the stability of PE over a two-year period. Seven hundred and twenty subjects will complete laboratory assessments of temperament, and 396 will be selected for further study, including laboratory assessments of EEG and parent-child interactions; a battery of interview and rating scale measures of temperament and psychopathology in the children and their parents; and a follow-up evaluation atage 5. The project has six specific aims: (1) examine the structure of PE, parse its core components, and distinguish it from the near-neighbor construct of behavioral inhibition (BI); (2) test hypothesized associations between low PE and two other markers of risk for depression: maternal history of mood disorders and asymmetries in EEG activity (decreased left frontal and right parietal activity); (3) investigate the specificity of the low PE-depression relationship by determining whether child low PE is related to non-mood disorders in parents and EEG asymmetries that have been implicated in some forms of anxiety disorders (increased right frontal and right parietal activity) and exploring whether other temperament variables, such as BI, are also associated with a parental history of mood disorders and decreased left frontal and right parietal EEG activity; (4) evaluate the stability of low PE between the ages of 3 and 5, and examine its relationship to BI over time; (5) identify factors that might moderate the developmental trajectory of low PE (and ultimately the development of depression), such as other temperament variables, parental mood disorders, and parenting behavior; and (6) build the foundation for a long-term study that follows the sample into adolescence/young adulthood in order to determine whether low PE at age 3 predicts the subsequent onset of depression.

描述（由申请人提供）：对抑郁症的前兆和早期表现知之甚少。最近的理论和实证工作的气质和情绪障碍的成人和儿童已经收敛在表明，气质低积极情绪（PE）可能是一个前兆，随后抑郁症。我们试图开始测试这一假设，评估气质在一个大的社区样本的3岁儿童，检查低PE和两个更好地建立抑郁症的危险因素之间的关系，并调查PE的稳定性超过两年的时间。720名受试者将完成气质的实验室评估，396名将被选择用于进一步研究，包括EEG和亲子互动的实验室评估;一组儿童及其父母的气质和精神病理学的访谈和评级量表测量;以及5岁时的随访评估。该项目有六个具体目标：（1）检查PE的结构，解析其核心成分，并将其与行为抑制（BI）的近邻结构区分开来;（2）测试低PE与其他两个抑郁症风险标志物之间的假设关联：情绪障碍的母亲病史和EEG活动的不对称性（左额叶和右顶叶活动减少）;（3）通过确定儿童低PE是否与父母的非情绪障碍以及与某些形式的焦虑障碍有关的EEG不对称有关，来研究低PE与抑郁关系的特异性。（4）评估3 - 5岁儿童低PE的稳定性，并研究其与BI的关系;（5）确定可能缓和低PE发展轨迹的因素（并最终发展为抑郁症），如其他气质变量、父母情绪障碍和养育行为;以及（6）为长期研究奠定基础，该研究将样本跟踪到青春期/青年期，以确定3岁时的低PE是否预示随后的抑郁症发作。