Temperamental emotionality in preschoolers and risk for depression

学龄前儿童的气质情绪和抑郁风险

• 批准号: 8826177
• 负责人: Daniel N Klein
• 金额: $ 70.89万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8826177
• 关键词: 3 year old; Accounting; Adolescence; Age; Aversive Stimulus; Behavioral; Behavioral inhibition; Child; Child Rearing; Childhood; Communities; Depressive disorder; Development; Developmental Process; Diagnosis; Disease; Distal; Early Intervention; Early identification; Emotional; Event-Related Potentials; Exhibits; Family; Feedback; Female; Foundations; Gender; Health; Hormones; Hydrocortisone; Knowledge; Laboratories; Life Stress; Link; Longevity; Longitudinal Studies; Major Depressive Disorder; Maps; Measures; Mediating; Mental Depression; Mental disorders; Morbidity - disease rate; National Institute of Mental Health; Negative Valence; Neurobiology; Outcome; Pathway interactions; Positive Valence; Preventive Intervention; Process; Process Measure; Psychopathology; Puberty; Research Domain Criteria; Rewards; Risk; Risk Factors; Role; Sampling; Stimulus; Strategic Planning; Stress; System; Temperament; Time; adolescent-onset depression; age effect; anxiety symptoms; base; clinically significant; depressive symptoms; economic cost; emerging adult; hypothalamic-pituitary-adrenal axis; indexing; information processing; mortality; peer; prevent; psychosocial; relating to nervous system; reward processing; social; stimulus processing

DESCRIPTION (provided by applicant): Major Depressive Disorder (MDD) is one of the most prevalent mental disorders, and is associated with significant mortality, morbidity, and economic costs. The Stony Brook Temperament Study is an ongoing longitudinal study that seeks to identify early behavioral precursors/risk factors for depression and understand the neurobiological and psychosocial processes through which these early manifestations develop into MDD. This information about risk pathways and processes should contribute to understanding when and how to intervene in order to prevent the disorder and limit its progression. The study initially assessed a large community sample of 3-year old children, followed them up at age 6, and is currently evaluating them in middle childhood (age 9). This competing renewal application seeks to extend the study into adolescence, the beginning of the peak risk period for onset of MDD. Specifically, the application proposes to map pathways from laboratory observations of low positive emotionality and high negative emotionality at age 3 to neural indices of emotional and social information processing, hypothalamic-pituitary-adrenal axis dysregulation, and emerging depressive and anxiety symptoms in early- (age 12) and mid- (age 15) adolescence. In addition, it seeks to understand the role of pubertal development and life stress in influencing these trajectories, and to capture the early portion of the expected sure in first-onset MDD that begins at puberty and continues through early adulthood.

描述（由申请人提供）：重度抑郁症（MDD）是最常见的精神障碍之一，与显著的死亡率、发病率和经济成本相关。斯托尼布鲁克气质研究是一项正在进行的纵向研究，旨在确定抑郁症的早期行为前兆/风险因素，并了解这些早期表现发展为MDD的神经生物学和心理社会学过程。这些关于风险途径和过程的信息应该有助于了解何时以及如何进行干预，以预防疾病并限制其进展。该研究最初评估了一个3岁儿童的大型社区样本，在6岁时对他们进行了随访，目前正在评估他们的童年中期（9岁）。这一竞争性更新申请旨在将研究扩展到青春期，即MDD发病高峰风险期的开始。具体而言，该申请提出将3岁时低积极情绪和高消极情绪的实验室观察结果映射到情绪和社会信息处理、下丘脑-垂体-肾上腺轴失调以及青春期早期（12岁）和中期（15岁）出现的抑郁和焦虑症状的神经指标。此外，它旨在了解青春期发育和生活压力在影响这些轨迹中的作用，并捕获从青春期开始并持续到成年早期的首发MDD的预期肯定的早期部分。