MASS ACTION OF NEOCORTEX

新皮质的大规模行动

• 批准号: 2245713
• 负责人: ALAN S GEVINS
• 金额: $ 42.03万
• 依托单位: EEG SYSTEMS LABORATORY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-01 至 1996-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2245713
• 关键词: cerebral cortex; communication disorders; computer simulation; electroencephalography; evoked potentials; generalized seizures; human subject; magnetic resonance imaging; mathematical model; mental process; model design /development; neocortex; neural information processing; perception; psychophysiology; sensorimotor system; sensory discrimination; stimulus /response; stimulus interval

The long-term objective of this project is to develop a theory of brain function that explains the dynamics of the cerebral cortex in the operations of sensation, perception, conception, memory and other cognitive processes. The long-term result is expected to be a set of procedures, based on a new understanding of the fundamental physical "code" underlying mental process, that would allow precise clinical evaluation of malfunctions of the brain's "information processing" in disorders such as schizophrenia. The specific aims of this project are: (1) to advance understanding of neurocognitive processes by providing more detailed and specific measurements of the spatial and temporal characteristics of neuroelectric neurocognitive signals; and (2) to test and extend theories and analytic methods of mass neural action developed in mammalian paleocortex to the human neocortex. This ill involve measuring detailed spatial patterns of low and high frequency neuroelectric activity related to stimulus, response and cognitive factors of a somatosensory-motor judgment task, including the tie intervals during which these patterns occur, the size and location of their spatial domains, and temporal spectral bands in which the activity is concentrated. We plan to do this first with recordings from subdural electrode grids implanted for diagnostic purposes in patients wit refractory seizures. Then we will extend the analysis to arrays of scalp electrodes, first from the same patients and then from healthy subjects. Substantive progress during the first 2 years of this grant includes: development of a task and methods to record and analyze EEGs from 124- electrode scalp arrays and 60-channel subdural electrode grids; completion of nine 124-channel calibration recordings during finger stimulation and 3 60-channel subdural grid recordings from patients performing the somatosensory discrimination task; development of unique algorithms and software for 3-dimensional compute reconstruction sand modeling of subjects' brains from Magnetic Resonance Images (MRIs); and extensive efforts to disseminate information about our methods and results to other researchers. Preliminary analysis of the subdural data suggests that analytic techniques originally developed for paleocortex will be applicable to the human neocortex. Preliminary analysis of the scalp EEG data and 3-D MRI brain models suggest that great improvements in functional localization from scalp-recorded data are forthcoming. In summary, the various components of the research program are all well underway, and we propose to continue with data collection, algorithm development, signal processing and data analysis. We expect the this project will result in substantial advances in measuring and understanding the mass neural substrate of human cognition.

这个项目的长期目标是发展一种大脑理论 功能，解释了大脑皮层的动力学， 感觉、知觉、概念、记忆和其他认知的操作 流程.长期的结果预计将是一套程序， 基于对基本物理“代码”的新理解， 心理过程，这将允许精确的临床评估， 大脑“信息处理”功能障碍，例如 精神分裂症该项目的具体目标是：（1）促进 了解神经认知过程，提供更详细， 空间和时间特征的具体测量 神经电神经认知信号;（2）测试和扩展理论 哺乳动物群体神经活动的分析方法 paleocortex到人类neocortex。这将涉及测量详细 低频和高频神经电活动的空间模式相关 躯体感觉运动的刺激、反应和认知因素 判断任务，包括领带间隔期间，这些模式 发生，其空间域的大小和位置，以及时间 活动集中的光谱带。我们计划这样做 第一种是从植入的硬膜下电极网格记录， 难治性癫痫患者的诊断目的。那么我们将 将分析扩展到头皮电极阵列，首先从相同的 患者，然后是健康受试者。 在该赠款的头两年取得的实质性进展包括： 开发一项任务和方法，记录和分析124- 头皮电极阵列和60通道硬膜下电极网格;完成 手指刺激期间的9个124通道校准记录和3个 60-通道硬膜下网格记录来自执行 体感辨别任务;开发独特的算法， 三维计算机重建砂体模型软件 受试者的大脑从磁共振图像（MRI）;和广泛的 努力传播有关我们的方法和结果的信息，以其他 研究人员对硬膜下数据的初步分析表明， 最初为古皮层开发的分析技术将是适用的 到人类大脑皮层。头皮脑电图数据的初步分析及三维重建 MRI大脑模型表明，功能定位的巨大改善 从头皮记录的数据中提取的信息 总之，研究计划的各个组成部分都很好 正在进行中，我们建议继续进行数据收集，算法 信号处理和数据分析。我们期待这个 该项目将在测量和理解方面取得实质性进展 人类认知的大量神经基质。