AUTORADIOGRAPHIC/MRI IMAGING OF CEREBRAL FUNCTION

脑功能的放射自显影/MRI 成像

• 批准号: 2266035
• 负责人: JAMES L LEAR
• 金额: $ 29.28万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-01 至 1997-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2266035
• 关键词: autoradiography; brain metabolism; central nervous system disorders; clinical biomedical equipment; laboratory rat; magnetic resonance imaging; nervous system disorder diagnosis; neurophysiology; radionuclide double label; radionuclide imaging /scanning

The overall purpose of this application is to refine existing techniques and to develop new biochemical models, methods, and experimental techniques for autoradiographic and magnetic resonance imaging of cerebral blood flow and metabolism and their interrelationships. The development of a very high performance, low cost imaging system for quantitative analysis and three dimensional processing and display of autoradiographic images will be completed. The system uses newly-developed memory-intensive, lookup table-based algorithms to achieve very rapid effective processing speeds on personal computers. The system will be used for three dimensional quantitative analysis of autoradiograms of cerebral blood flow and metabolism tracers in animals. Double and triple label autoradiographic techniques will be developed for concurrent and sequential tracer studies. Using these techniques, the kinetics of various metabolic tracers will be compared. Results of these studies will be used to evaluate existing kinetic models, and to assess the significance and limitations of their basic assumptions. From this base, new methods for estimatiOn of cerebral glycolysis and oxidation will be developed. The metabolic studies will then be combined with studies of blood flow under normal and abnormal conditions. Based on autoradiographic studies, corresponding magnetic resonance (MR) imaging and spectroscopic studies will be performed In humans to evaluate the relationships between cerebral blood flow (deoxyhemoglobin-shift imaging) and cerebral metabolism (lactate spectroscopy). The basic understanding of cerebral metabolism and blood flow provided by these studies will promote greater understanding of the function of the brain in normal and pathological conditions in animal models (autoradiography) and in humans (MR).

此应用程序的总体目的是改进现有的 技术和开发新的生物化学模型，方法， 放射自显影和磁共振实验技术 脑血流和代谢显像及其 相互关系。 高性能、低成本成像系统的开发 用于定量分析和三维处理， 将完成放射自显影图像的显示。 系统 使用新开发的内存密集型、基于查找表的 算法，以实现非常快速有效的处理速度， 个人电脑。该系统将用于三维 脑血流放射自显影定量分析， 动物体内的代谢示踪剂。 将采用双标记和三标记放射自显影技术， 开发用于并行和连续示踪剂研究。使用这些 技术，各种代谢示踪剂的动力学将是 比较了这些研究的结果将用于评估 现有的动力学模型，并评估的意义和 其基本假设的局限性。在此基础上，新方法 估计大脑糖酵解和氧化将是 开发然后将代谢研究与 在正常和异常情况下的血液流动。 根据放射自显影研究，相应的磁共振成像 (MR)成像和光谱学研究将在人类身上进行， 以评估脑血流与 （脱氧血红蛋白移位成像）和脑代谢（乳酸 光谱学）。 对脑代谢和血流的基本认识 这些研究提供的信息将促进对 在正常和病理条件下的大脑功能， 动物模型（放射自显影）和人体（MR）。