AUTORADIOGRAPHIC IMAGING OF CEREBRAL FUNCTIONS

本应用程序的总体目的是改进现有技术 并开发放射自显影的新方法和技术 脑血流和代谢显像及其 相互关系 高性能、低成本成像系统 用于定量分析和三维处理和显示 放射自显影图像将被开发。 该系统将在 用于分析脑血流的放射自显影图， 动物体内的代谢示踪剂。 使用dobule和triple label 放射自显影，流动和代谢的各种示踪剂的动力学 将被比较。 这些研究的结果将用于评估 现有动力学模型，并评估其重要性和局限性 的基本假设。 然后，成像系统将与 临床成像仪器，例如伽马照相机， 动物研究可以直接应用于患者数据。

The overall purpose of this application is to refine existing techniques and to develop new methodology and technology for autoradiographic imaging of cerebral blood flow and metabolism and their interrelationships. A very high performance, low cost imaging system for quantitative analysis and three dimensional processing and display of autoradiographic images will be developed. The system will then be used for analysis of autoradiograms of cerebral blood flow and metabolism tracers in animals. Using dobule and triple label autoradiography, the kinetics of various tracers of flow and metabolism will be compared. Results of these studies will be used to evaluate the existing kinetic models, and to assess the significance and limitations of basic assumptions. The imaging system will then be interfaced to clinical imaging instruments such as gamma cameras so that the resuls of the animal studies can be directly applied to patient data.