AUTORADIOGRAPHIC IMAGING OF CEREBRAL FUNCTIONS

脑功能放射自显影

• 批准号: 3412635
• 负责人: JAMES L LEAR
• 金额: $ 18.97万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-01 至 1992-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3412635
• 关键词: autoradiography; brain metabolism; central nervous system disorders; cerebrum; clinical biomedical equipment; laboratory rat; nervous system disorder diagnosis; radionuclide imaging /scanning

The overall purpose of this application is to refine existing techniques and to develop new methodology and technology for autoradiographic imaging of cerebral blood flow and metabolism and their interrelationships. A very high performance, low cost imaging system for quantitative analysis and three dimensional processing and display of autoradiographic images will be developed. The system will then be used for analysis of autoradiograms of cerebral blood flow and metabolism tracers in animals. Using dobule and triple label autoradiography, the kinetics of various tracers of flow and metabolism will be compared. Results of these studies will be used to evaluate the existing kinetic models, and to assess the significance and limitations of basic assumptions. The imaging system will then be interfaced to clinical imaging instruments such as gamma cameras so that the resuls of the animal studies can be directly applied to patient data.

此应用程序的总体目的是改进现有技术 开发放射自显影的新方法和新技术 脑血流和代谢的成像及其临床意义 相互关系。一种非常高性能、低成本的成像系统 用于定量分析和三维处理和显示 将开发放射自显影图像。然后，该系统将被 用于分析脑血流的放射自显影和 动物体内的代谢示踪剂。使用Dobule和Triple标签 放射自显影，各种流动和代谢示踪剂的动力学 将会被比较。这些研究的结果将用来评估 现有的动力学模型，并评估其意义和局限性 基本假设。成像系统随后将连接到 临床成像仪器，如伽马相机，以使结果 动物研究可以直接应用于患者数据。