NEUROBEHAVIORAL MODEL OF CNS LYME DISEASE

中枢神经系统莱姆病的神经行为模型

• 批准号: 2274261
• 负责人: ANDREW R PACHNER
• 金额: $ 24.94万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2274261
• 关键词: Borrelia; Lyme disease; behavior test; cytokine; disease /disorder model; electron microscopy; enzyme linked immunosorbent assay; gene expression; genetic strain; laboratory mouse; nervous system infection; neuropsychology; polymerase chain reaction

CNS Lyme disease is an increasingly prevalent cause of neuropsychiatric disease in the United States. It can be difficult to diagnose, mimicking dementing syndromes or psychiatric disease. The early diagnosis of CNS Lyme disease is important because it is treatable with antibiotics; however, the optimum dose and duration of treatment has not been determined. The combination of increasing prevalence and difficulties with diagnosis and treatment make this illness of increasing importance. The pathogenesis of CNS Lyme disease remains unknown. Chronic infection of the brain with B. burgdorferi appears most likely but has not been demonstrated. The involvement of cytokines or other inflammatory molecules has been postulated. Progress has thus far been poor in understanding pathogenesis because of the lack of an adequate animal model of Lyme borreliosis. We propose to study CNS Lyme disease in a recently developed murine model of Lyme borreliosis. The major questions that will be answered by this project will be: Are behavioral changes associated with chronic infection of the brain? What areas of the brain and what cell types are involved? Is susceptibility to CNS Lyme disease genetically determined? Can different strains of the organism cause varying degrees of encephalopathy? Is increased gene expression of cytokines or other inflammatory molecules associated with infection or behavioral changes? This proposal will lead to improved understanding of the pathogenesis of neuropsychiatric disturbances in CNS Lyme disease and chronic infections in general.

中枢神经系统莱姆病是神经精神疾病日益普遍的原因 疾病发生在美国。诊断、模仿可能很困难 痴呆综合症或精神疾病。中枢神经系统的早期诊断 莱姆病很重要，因为它可以用抗生素治疗。 但最佳剂量和治疗持续时间尚未确定 决定。日益增加的患病率和困难的结合 诊断和治疗使这种疾病变得越来越重要。 中枢神经系统莱姆病的发病机制仍不清楚。慢性感染 大脑中最有可能存在伯氏疏螺旋体，但尚未发现 证明了。细胞因子或其他炎症分子的参与 已被假设。迄今为止，在理解方面进展甚少 由于缺乏适当的莱姆病动物模型而导致的发病机制 疏螺旋体病。 我们建议在最近开发的小鼠模型中研究中枢神经系统莱姆病 莱姆疏螺旋体病。本次会议将回答的主要问题 项目将是： 行为改变是否与慢性感染相关 大脑的？涉及大脑的哪些区域以及哪些细胞类型？是 中枢神经系统莱姆病的易感性由基因决定吗？可以不同 生物体菌株引起不同程度的脑病？是 细胞因子或其他炎症分子的基因表达增加 与感染或行为改变有关吗？ 该提议将有助于加深对疾病发病机制的了解 中枢神经系统莱姆病和慢性感染的神经精神障碍 一般来说。