NEUROBEHAVIORAL MODEL OF CNS LYME DISEASE

中枢神经系统莱姆病的神经行为模型

• 批准号: 2274261
• 负责人: ANDREW R PACHNER
• 金额: $ 24.94万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2274261
• 关键词: Borrelia; Lyme disease; behavior test; cytokine; disease /disorder model; electron microscopy; enzyme linked immunosorbent assay; gene expression; genetic strain; laboratory mouse; nervous system infection; neuropsychology; polymerase chain reaction

CNS Lyme disease is an increasingly prevalent cause of neuropsychiatric disease in the United States. It can be difficult to diagnose, mimicking dementing syndromes or psychiatric disease. The early diagnosis of CNS Lyme disease is important because it is treatable with antibiotics; however, the optimum dose and duration of treatment has not been determined. The combination of increasing prevalence and difficulties with diagnosis and treatment make this illness of increasing importance. The pathogenesis of CNS Lyme disease remains unknown. Chronic infection of the brain with B. burgdorferi appears most likely but has not been demonstrated. The involvement of cytokines or other inflammatory molecules has been postulated. Progress has thus far been poor in understanding pathogenesis because of the lack of an adequate animal model of Lyme borreliosis. We propose to study CNS Lyme disease in a recently developed murine model of Lyme borreliosis. The major questions that will be answered by this project will be: Are behavioral changes associated with chronic infection of the brain? What areas of the brain and what cell types are involved? Is susceptibility to CNS Lyme disease genetically determined? Can different strains of the organism cause varying degrees of encephalopathy? Is increased gene expression of cytokines or other inflammatory molecules associated with infection or behavioral changes? This proposal will lead to improved understanding of the pathogenesis of neuropsychiatric disturbances in CNS Lyme disease and chronic infections in general.

中枢神经系统莱姆病是神经精神病的越来越普遍的原因 美国疾病。很难诊断，模仿 痴呆综合征或精神病。中枢神经系统的早期诊断 莱姆病很重要，因为它可以用抗生素治疗。 但是，最佳剂量和治疗持续时间尚未 决定。越来越多的患病率和困难与 诊断和治疗使这种疾病的重要性越来越大。 中枢神经系统莱姆病的发病机理尚不清楚。慢性感染 大脑与B. burgdorferi看起来很可能，但没有 证明。细胞因子或其他炎症分子的参与 已经假设了。迄今为止的进步很差 由于缺乏适当的莱姆动物模型，因此发病机理 毛毛病。 我们建议在最近开发的鼠模型中研究CNS莱姆病 莱姆毛毛虫病。将要回答的主要问题 项目将是：是与慢性感染相关的行为改变 大脑？涉及哪些大脑区域以及涉及哪些细胞类型？是 CNS莱姆病遗传确定的易感性？可以不同 生物体的菌株会导致不同程度的脑病？是 细胞因子或其他炎症分子的基因表达增加 与感染或行为改变有关？ 该提议将导致人们对 中枢神经系统莱姆病和慢性感染的神经精神障碍 一般来说。