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NON-HUMAN PRIMATE ANIMAL MODELS FOR RSCH ON CHRONIC LYME

NON-HUMAN PRIMATE ANIMAL MODELS FOR RSCH ON CHRONIC LYME
慢性莱姆病 RSCH 的非人类灵长类动物模型
批准号：
6367918
负责人：
ANDREW R PACHNER
金额：
$25.98万
依托单位：
UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-06-14 至 2004-06-13
来源：
https://reporter.nih.gov/project-details/6367918
关键词：
Borrelia Lyme disease Primates biomedical facility disease /disorder model host organism interaction microorganism immunology model design /development nervous system disorder

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中文摘要
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英文摘要
The objectives of this contract are to gain knowledge about infection of the nervous system with Borrelia burgdorferi in the Rhesus macaque animal model that would aid in the diagnosis and treatment of human Lyme neuroborreliosis (LNB). This includes: (a) optimizing the current experimental model of LNB in non-human primates; (b) learning more about neurotropism and neuropathogenicity in the expression of LNB, as well as the mechanisms involved; and (c) determining whether long-term infection with B. burgdorferi results in damage to the central and/or peripheral nervous system.
期刊论文(3)
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科研奖励(0)
会议论文
Genotype determines phenotype in experimental Lyme borreliosis.
基因型决定实验性莱姆疏螺旋体病的表型。
DOI： 10.1002/ana.20192
发表时间： 2004
期刊： Annals of neurology
影响因子： 11.2
作者： [Pachner,AndrewR, Dail,Donna, Bai,Yunhong, Sondey,Marie, Pak,Lena, Narayan,Kavitha, Cadavid,Diego]
通讯作者： Cadavid,Diego
DIAGNOSIS AND THERAPY OF LYME NEUROBORRELIOSIS USING THE MONKEY MODEL
NON-HUMAN PRIMATE ANIMAL MODELS FOR RSCH ON CHRONIC LYME
NON-HUMAN PRIMATE ANIMAL MODELS FOR RSCH ON CHRONIC LYME
PATHOGENESIS OF NEUROBORRELIOSIS
  • 批准号：
    2038088
  • 项目类别：
  • 资助金额：
    $27.36万
  • 财政年份：
    1997
  • 负责人：
    ANDREW R PACHNER
  • 依托单位：
    GEORGETOWN UNIVERSITY
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