PATHOGENESIS OF NEUROBORRELIOSIS

神经疏螺旋体病的发病机制

• 批准号: 2038088
• 负责人: ANDREW R PACHNER
• 金额: $ 27.36万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2038088
• 关键词: Borrelia; Macaca mulatta; borreliosis; host organism interaction; immunocytochemistry; infectious meningitis; microorganism immunology; neuropathology; pathologic process; polymerase chain reaction; virulence

Lyme neuroborreliosis (LNB) is an increasingly prevalent cause of neurological disease in the world. The infection results in chronic meningitis, cranial nerve lesions, chronic disorders of memory and cognitive functioning, and peripheral nerve damage. Very little is known about pathogenesis of the infection in the central nervous system (CNS). This ignorance about the pathogenesis of LNB has prompted laborious and excessively expensive diagnostic procedures, as well as bizarre and frequently toxic treatments: For instance, we do not know: how frequently the spirochete invades the CNS after intradermal injection how long the infection persists in the CNS the CNS cell type and location infected whether the immune system plays a significant role in the CNS infection whether spirochetes invade peripheral nerves This project will address these areas of ignorance, using a model of LNB in Rhesus macaques recently developed in our laboratory. The information gained will lead to an understanding of pathogenesis as well as the development of rationale diagnostic strategies and safe, effective therapy. It will also lead to a greater understanding of chronic infections of the CNS.

莱姆神经红细胞增多（LNB）是越来越普遍的原因 世界上神经疾病。 感染导致慢性 脑膜炎，颅神经病变，记忆的慢性疾病和 认知功能和周围神经损伤。 很少 关于中枢神经中感染的发病机理已知 系统（CNS）。 关于LNB发病机理的这种无知 促使费力且过于昂贵的诊断程序 以及奇怪而经常有毒的治疗方法： 例如，我们不知道： 螺旋体在皮内侵入中枢神经系统的频率 注射 中枢神经系统的感染持续多长时间 CNS单元格类型和位置感染 免疫系统是否在CNS中起重要作用 感染 螺旋体是否入侵周围神经 该项目将使用一个模型来解决这些无知领域 LNB在恒河猕猴中最近在我们的实验室中开发。 这 获得的信息将导致对发病机理的理解 以及基本原理诊断策略和安全的发展， 有效的疗法。 这也将导致对 中枢神经系统的慢性感染。