NON-HUMAN PRIMATE ANIMAL MODELS FOR RSCH ON CHRONIC LYME

慢性莱姆病 RSCH 的非人类灵长类动物模型

• 批准号: 6334073
• 负责人: ANDREW R PACHNER
• 金额: $ 67.44万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-14 至 2004-06-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6334073
• 关键词: Borrelia; Lyme disease; Primates; biomedical facility; disease /disorder model; host organism interaction; microorganism immunology; model design /development; nervous system disorder

The objectives of this contract are to gain knowledge about infection of the nervous system with Borrelia burgdorferi in the Rhesus macaque animal model that would aid in the diagnosis and treatment of human Lyme neuroborreliosis (LNB). This includes: (a) optimizing the current experimental model of LNB in non-human primates; (b) learning more about neurotropism and neuropathogenicity in the expression of LNB, as well as the mechanisms involved; and (c) determining whether long-term infection with B. burgdorferi results in damage to the central and/or peripheral nervous system.

该合同的目标是在恒河猴动物模型中获得有关神经系统感染的知识，该模型将有助于诊断和治疗人类莱姆神经性的诊断和治疗。这包括：（a）优化非人类灵长类动物中LNB的当前实验模型； （b）更多地了解LNB表达中的神经性和神经病性以及所涉及的机制； （c）确定长期感染B. burgdorferi是否会损害中央和/或周围神经系统。