NON-HUMAN PRIMATE ANIMAL MODELS FOR RSCH ON CHRONIC LYME

慢性莱姆病 RSCH 的非人类灵长类动物模型

• 批准号: 6334073
• 负责人: ANDREW R PACHNER
• 金额: $ 67.44万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-14 至 2004-06-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6334073
• 关键词: Borrelia; Lyme disease; Primates; biomedical facility; disease /disorder model; host organism interaction; microorganism immunology; model design /development; nervous system disorder

The objectives of this contract are to gain knowledge about infection of the nervous system with Borrelia burgdorferi in the Rhesus macaque animal model that would aid in the diagnosis and treatment of human Lyme neuroborreliosis (LNB). This includes: (a) optimizing the current experimental model of LNB in non-human primates; (b) learning more about neurotropism and neuropathogenicity in the expression of LNB, as well as the mechanisms involved; and (c) determining whether long-term infection with B. burgdorferi results in damage to the central and/or peripheral nervous system.

该合同的目的是获得有关恒河猴动物模型中伯氏疏螺旋体神经系统感染的知识，这将有助于诊断和治疗人类莱姆病神经疏螺旋体病（LNB）。这包括：（a）优化目前在非人灵长类动物中LNB的实验模型;（B）了解更多关于LNB表达的嗜神经性和神经致病性，以及所涉及的机制;和（c）确定是否长期感染B。伯氏病导致中枢和/或外周神经系统的损伤。