Targeting conjugated markers with new metabolomic methods

使用新的代谢组学方法靶向缀合标记

• 批准号: LP180100421
• 负责人: Prof Malcolm McLeod
• 金额: $ 22.03万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-09-30 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP180100421
• 关键词: Targeting; conjugated; markers; new; metabolomic

Detecting the illicit use of natural steroids like testosterone, or compounds that modulate natural steroid levels, remains the greatest challenge for drug testing in all forms of sport. This project aims to develop new metabolomic methods based on liquid chromatography-high resolution mass spectrometry to detect the changes occurring in the conjugated steroid profile following the administration of steroids or steroid modulators. The intended outcome will be a set of sensitive and analytical methods using a range of newly identified conjugated steroid markers and associated reference materials, which promises to enhance integrity and animal welfare in the thoroughbred racing industry.

检测睾酮等天然类固醇或调节天然类固醇水平的化合物的非法使用仍然是所有运动形式中药物检测的最大挑战。该项目旨在开发基于液相色谱-高分辨率质谱的新代谢组学方法，以检测施用类固醇或类固醇调节剂后缀合类固醇谱发生的变化。预期的结果将是使用一系列新发现的共轭类固醇标记物和相关参考材料建立一套灵敏的分析方法，这有望提高纯种赛马行业的完整性和动物福利。