Strategies for the detection of designer steroids in greyhounds

灵缇犬中设计类固醇的检测策略

• 批准号: LP160100075
• 负责人: Prof Malcolm McLeod
• 金额: $ 29.54万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-11-08 至 2020-11-07
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160100075
• 关键词: Strategies; detection; designer; steroids; greyhounds

Strategies for the detection of designer steroids in greyhounds. This project aims to develop strategies to detect designer steroids in racing greyhounds to safeguard industry integrity and animal welfare. These strategies include in vivo and comparative in vitro studies of steroid metabolism, mass-spectrometric elucidation of metabolite structures, and synthesis of putative steroid metabolites with different stereochemistries and oxidation patterns as reference materials. This project will use major metabolites identified by these studies to develop analytical procedures to test for drug abuse at greyhound race meetings. The project will target twelve readily available designer steroid supplements that have significant risk of abuse.

灰狗体内特制类固醇的检测策略。该项目旨在开发策略，以检测赛狗中的设计师类固醇，以维护行业诚信和动物福利。这些策略包括类固醇代谢的体内和体外比较研究，代谢物结构的质谱学阐明，以及以不同的立体化学和氧化模式为参照物合成类固醇代谢物。该项目将使用这些研究确定的主要代谢物来开发分析程序，以测试灰狗比赛中的药物滥用情况。该项目将针对12种容易获得的有严重滥用风险的设计师类固醇补充剂。