Synthesis of the pyrrolo[2,1-c][1,4]benzodiazepines: potent DNA binders

吡咯并[2,1-c][1,4]苯二氮卓类药物的合成：有效的 DNA 结合剂

• 批准号: DP0451515
• 负责人: Prof Malcolm McLeod
• 金额: $ 22.98万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-03-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0451515
• 关键词: Synthesis; pyrrolo; benzodiazepines; potent; DNA

Chemicals that bind to DNA have a long history of use as anticancer drugs. In recent times, the biotechnology revolution has greatly expanded our understanding of how these drugs work and the genetic basis of a wide range of other diseases. The aim of this project is to discover novel compounds that selectively bind to DNA. Starting from a class of naturally occurring compounds (called the pyrrolobenzodiazepines) as a template, it will develop powerful new methods to supply wholly new DNA interactive molecules with great potential as new drugs to treat cancer or other genetic diseases.

与DNA结合的化学物质作为抗癌药物的使用由来已久。最近，生物技术革命极大地扩展了我们对这些药物如何起作用以及其他一系列疾病的遗传基础的理解。这个项目的目的是发现选择性地与DNA结合的新化合物。从一类天然存在的化合物(称为吡咯洛苯并二氮卓类化合物)作为模板，它将开发出强大的新方法，为全新的DNA相互作用分子提供巨大的潜力，作为治疗癌症或其他遗传疾病的新药。