Elucidating the Mode of Action of Nicotinic Receptor Ligands

阐明烟碱受体配体的作用模式

• 批准号: DP0986469
• 负责人: Prof Malcolm McLeod
• 金额: $ 29.04万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0986469
• 关键词: Elucidating; Mode; Action; Nicotinic; Receptor

Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly where they act in the brain.

大脑功能的改变会引起人类疾病，如癫痫、精神分裂症和阿尔茨海默病。为了开发治疗这些疾病的新药，我们需要研究药物在大脑中的作用。该项目将使用新的化学方法来制造药物，然后在重要的大脑受体上测试其生物活性。这将告诉我们哪些化合物是最有效的潜在药物，以及它们在大脑中的确切位置。