Total Synthesis of the Microsclerodermins: Anti-fungal Cyclic Peptides

真菌感染是日益增加的免疫功能低下患者群体中发病率和死亡率的主要原因之一，所述免疫功能低下患者群体包括AIDS、化疗和器官移植患者。该项目的目的是发现新的抗真菌治疗耐药致病性真菌感染，基于microsclerodermin家族的天然产物。从自然环境中分离的少量微硬皮病阻碍了从这种天然产物中开发抗真菌剂。将开发创新的合成方法来制备大量的microsclerodermins和相关化合物用于生物测试，从而进一步开发这类有前途的抗真菌药物。

Fungal infections are one of the major causes of morbidity and mortality in the increasing immunocompromised patient population, which includes AIDS, chemotherapy and organ transplant patients. The aim of this project is to discover new anti-fungal treatments for drug-resistant pathogenic fungal infections, based on the microsclerodermin family of natural products. The small quantity of microsclerodermin isolated from the natural environment hampers the development of anti-fungal agents from this natural product. Innovative synthetic methods will be developed to prepare large quantities of microsclerodermins and related compounds for biological testing, thereby furthering the development of this promising class of anti-fungal drugs.