New Imaging Agents for Neuronal Nicotinic Receptors

神经元烟碱受体的新型成像剂

• 批准号: LP0454997
• 负责人: Prof Malcolm McLeod
• 金额: --
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0454997
• 关键词: New; Imaging; Agents; Neuronal; Nicotinic

Recent advances in medical imaging technology such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) have radically improved the diagnosis and treatment of a wide range of diseases. The aim of this project is to discover novel radio-ligands that selectively bind to neuronal nicotinic acetylcholine receptors. These ligands will have great potential for the imaging, diagnosis and study of neurodegenerative diseases such as Alzheimer's disease.

医学成像技术的最新进展，如正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT），从根本上改善了广泛的疾病的诊断和治疗。本项目的目的是发现新的放射性配体，选择性地结合神经元烟碱乙酰胆碱受体。这些配体将在阿尔茨海默病等神经退行性疾病的成像、诊断和研究中具有巨大的潜力。