CRYO ROP PARTICIPATING CENTER--PHASE III

第三阶段具体目标： CRYO-ROP随访随机化部分的具体目的 研究的目的是解决以下问题： I. 眼睛是否有长期的结构或功能性后遗症 用冷冻疗法治疗的阈值ROP（与 未治疗），需要重新评价风险/获益比 推荐冷冻疗法吗 2. 研究数据是否表明冷冻治疗的“阈值”应该 降低？ 每年在7岁、8岁、9岁和10岁时进行眼科检查 在随机化的ROP患者中。 CRYO-ROP的自然历史部分的具体目标如下- 研究只涉及那些没有发展ROP的CRYO-ROP儿童， 婴儿将在7岁、9岁和10岁时进行检查 在这些研究患者中，数据收集旨在解决 与III期随机研究相同的眼部状态问题 患者

Phase III Specific Aims: The specific aims of the randomized portion of the CRYO-ROP follow-up study are to address the following questions: I. Are there long-term structural or functional ocular sequelae in eyes with Threshold ROP that are treated with cryotherapy (vs. those that are not treated) that would require re-evaluation of the risk/benefit ratio of recommending cryotherapy? 2. Do the study data suggest that the "threshold" for cryotherapy should be lowered? Yearly eye examinations will be performed at 7, 8, 9, and 10 years of age in the randomized ROP patients. The specific aims of the Natural History portion of the CRYO-ROP follow- up study involve only those CRYO-ROP children who did not develop ROP as an infant. Examinations will be performed at 7, 9, and 10 years of age in these study patients and data collection is designed to address the same ocular status question as the Phase III study of randomized patients.