HLA CLASS I MOLECULES AND THE CTL RESPONSE TO HIV

描述：此应用程序的目标是更好地了解 细胞毒性T淋巴细胞在识别和破坏红斑狼疮中的作用 感染艾滋病毒的细胞。调查员特别关注这一角色 编码I类分子的主要组织相容性复合体及其 与多肽的相互作用。他使用了分子生物学技术 生物学和细胞免疫学制定策略，以改善 多肽表位本身并使用了各种递送系统在 尝试改善对细胞和实验动物的传递。的 特别的新奇之处在于使用转基因小鼠产生细胞毒 对HIV编码蛋白的应答，但使用人类MHC多肽 结合分子以更好地模拟人类抗原呈递。这些 实验的设计是为了更好地理解，并且是有针对性的 朝着更合理的疫苗设计和投放系统迈进。

DESCRIPTION: The objective of this application is to better understand the role of cytotoxic T lymphocytes in the recognition and destruction of HIV-infected cells. The investigator has particularly focused on the role of major histocompatibility complex encoded class I molecules and their interactions with peptides. He has used the technologies of molecular biology and cellular immunology to devise strategies for improving the peptide epitopes themselves and used a variety of delivery systems in an attempt to improve delivery to cells and to experimental animals. Of particular novelty is the use of transgenic mice to produce cytotoxic responses to HIV encoded proteins, but which use the human MHC peptide binding molecules to better mimic human antigen presentation. These experiments are designed to allow a better understanding and are pointed towards more rational vaccine design and delivery systems.