CALCIUM PHOSPHATE CEMENTS

磷酸钙水泥

• 批准号: 2414706
• 负责人: LAURENCE C. CHOW
• 金额: $ 14.3万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2414706
• 关键词: bicarbonates; biomaterial development /preparation; biomaterial evaluation; biomechanics; calcium phosphate; cementum; crystallization; dental bonding material; hardness; hydroxyapatites; potassium; sodium; solid state; solubility; solutions; stoichiometry; tensile strength

Self-hardening calcium phosphate cements (CPC), developed under a NIH grant (DE05030), have proven useful in a number of dental and medical applications for which currently available materials do not work well. Results from animal studies indicated that improvements in several key properties of CPC can significantly increase the usefulness of the cement in clinical applications. The objectives of the proposed research are to elucidate mechanisms of reactions between calcium phosphate compounds that form cements and to understand physicochemical and mechanical properties of the cements formed under different conditions. The specific aims are: 1. To study the crystallinity, solubility, and rate of dissolution of the nearly stoichiometric hydroxyapatite (OHAp) formed in different cement systems and in CPCs that harden slowly or rapidly. Additionally, to determine the mechanical properties of the cements formed under these conditions. 2. To study the degree of Ca-deficiency, crystallinity, solubility, and rate of dissolution of OHAp formed in cements that have an overall Ca/P molar ratio below 1.67, and to study the mechanical properties of these cements. 3. To study the extent and the nature of carbonate incorporation, crystallinity, solubility, and rate of dissolution of OHAp formed in different cement systems and with either sodium or potassium as the cationic component of the carbonate source. 4. To study the rate of dissolution of cements that contain varied amounts of micropores (pore size of lessor 1 mum) and micropores (pore size of 150 2 200 mum). The information obtained from the proposed should be valuable in designing CPCs with specific in vitro and in vivo properties that are best suited for different types of clinical applications.

由美国国立卫生研究院资助开发的自硬性磷酸钙骨水泥(CPC) (DE05030)，已被证明在许多牙科和医疗 目前可用的材料不适用的应用程序。 动物研究的结果表明，几个关键因素的改善 CPC的性能可以显著提高水泥的使用性能 在临床应用中。拟议研究的目标是 阐明磷酸钙化合物之间的反应机理 形成水泥并了解其物理化学和力学性能 胶结物是在不同条件下形成的。具体目标是： 1.研究其结晶度、溶解度和溶出速度。 不同水泥中形成的近化学计量比羟基磷灰石(OHAp) 系统和CPC中缓慢或快速硬化的。此外，还可以 测定在这些材料下形成的水泥的力学性能 条件。 2.研究缺钙程度、结晶度、溶解度和 总钙磷比高的胶结物中OHAp的溶解速率 摩尔比低于1.67，并研究这些材料的力学性能 水泥。 3.研究碳酸盐掺入的程度和性质， 形成的OHAp的结晶度、溶解度和溶解速度 不同的水泥体系，以钠或钾为基料 碳酸盐来源的阳离子成分。 4.研究不同掺量水泥的溶解速度 微孔(出租人1微米大小)和微孔(150微孔 2200毫微米)。 从建议中获得的信息应该在设计中有价值 具有特定的体外和体内特性的CPC，最适合于 不同类型的临床应用。