CALCIUM PHOSPHATE CEMENTS

磷酸钙水泥

• 批准号: 2701014
• 负责人: LAURENCE C. CHOW
• 金额: $ 14.45万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2701014
• 关键词: bicarbonates; biomaterial development /preparation; biomaterial evaluation; biomechanics; calcium phosphate; cementum; crystallization; dental bonding material; hardness; hydroxyapatites; potassium; sodium; solid state; solubility; solutions; stoichiometry; tensile strength

Self-hardening calcium phosphate cements (CPC), developed under a NIH grant (DE05030), have proven useful in a number of dental and medical applications for which currently available materials do not work well. Results from animal studies indicated that improvements in several key properties of CPC can significantly increase the usefulness of the cement in clinical applications. The objectives of the proposed research are to elucidate mechanisms of reactions between calcium phosphate compounds that form cements and to understand physicochemical and mechanical properties of the cements formed under different conditions. The specific aims are: 1. To study the crystallinity, solubility, and rate of dissolution of the nearly stoichiometric hydroxyapatite (OHAp) formed in different cement systems and in CPCs that harden slowly or rapidly. Additionally, to determine the mechanical properties of the cements formed under these conditions. 2. To study the degree of Ca-deficiency, crystallinity, solubility, and rate of dissolution of OHAp formed in cements that have an overall Ca/P molar ratio below 1.67, and to study the mechanical properties of these cements. 3. To study the extent and the nature of carbonate incorporation, crystallinity, solubility, and rate of dissolution of OHAp formed in different cement systems and with either sodium or potassium as the cationic component of the carbonate source. 4. To study the rate of dissolution of cements that contain varied amounts of micropores (pore size of lessor 1 mum) and micropores (pore size of 150 2 200 mum). The information obtained from the proposed should be valuable in designing CPCs with specific in vitro and in vivo properties that are best suited for different types of clinical applications.

自硬化磷酸钙水泥 (CPC)，在 NIH 资助下开发 (DE05030)，已被证明在许多牙科和医疗领域有用 当前可用材料不能很好地发挥作用的应用。 动物研究结果表明，几个关键方面的改进 CPC的特性可以显着提高水泥的有用性 在临床应用中。 拟议研究的目标是 阐明磷酸钙化合物之间的反应机制 形成水泥并了解其物理化学和机械性能 不同条件下形成的水泥。 具体目标是： 1. 研究药物的结晶度、溶解度和溶出速率 不同水泥中形成的接近化学计量的羟基磷灰石 (OHAp) 缓慢或快速硬化的系统和 CPC 中。 另外，为了 确定在这些条件下形成的水泥的机械​​性能 状况。 2. 研究钙的缺乏程度、结晶度、溶解度和 具有总 Ca/P 的水泥中形成的 OHAP 的溶解速率 摩尔比低于1.67，并研究这些材料的机械性能 水泥。 3. 研究碳酸盐结合的程度和性质， OHAP 的结晶度、溶解度和溶解速率 不同的水泥体系，并以钠或钾作为 碳酸盐源的阳离子组分。 4. 研究不同含量水泥的溶解速率 微孔（孔径小于1μm）和微孔（孔径150μm） 2200 妈妈）。 从提案中获得的信息应该对设计有价值 CPC 具有特定的体外和体内特性，最适合 不同类型的临床应用。