CALCIUM PHOSPHATE BONE REPAIR MATERIALS

磷酸钙骨修复材料

基本信息

项目摘要

DESCRIPTION (Adapted from the Investigator's Abstract): A calcium phosphate cement (CPC), developed under this research project, was approved by the FDA in 1996 for cranial defects repair applications in humans, thus becoming the first material of its kind to be available for clinical use. While CPCs were shown to be very useful in a number of dental and medical applications for which other materials do not work well, in vivo study results suggest that in order to achieve the best results, CPC should have handling and in vivo properties that are best suited for the particular clinical application. The objectives of the proposed research are to elucidate mechanisms of cement setting reactions and to understand the physicochemical factors that influence cements= handling and in vivo properties. Four specific aims are proposed. Aim 1 proposes to understand factors that control the hydrolysis reactions of tetracalcium phosphate (TTCP), alpha-tricalcium phosphate (alpha-TCP), dicalcium phosphate dihydrate (DCPD), dicalcium phosphate anhydrous (DCPA) and calcium hydroxide. These calcium phosphate salts are the major components of different CPCs. Hydrolysis of one or more of the salts that form hydroxyapatite (HA) is responsible for the hardening of the cement. A better understanding of the hydrolysis reaction of each of these salts will provide important insights into factors that influence some important cement properties, including the rate of conversion to HA, formation of Ca-deficient or stoichiometric HA, the crystallinity HA, etc. Defective or non-stoichiometric HAs are believed to be more bioresorbable. Aim 2 proposes to study the dissolution rate of cement products in demineralizing solutions having ionic compositions mimicking the acidic environment produced by osteoclasts. A dual constant-composition titration system was developed during the report period for measuring dissolution rates of calcium phosphate biomaterials under simulated acidified physiological solutions. The Principal Investigator proposes to use this technique as an in vitro model for predicting resorption rates of CPC and to understand factors that control the dissolution rate. Aim 3 proposes to study properties of non-rigid and resorbable calcium phosphate cements. Experiments are described to study composites of CPC and chitosan, a biocompatible polymer to form self-hardening, bioresorbable, and non-rigid bone graft materials. These materials should be useful in a number of applications in which the implant can remain stable and firmly attached to the bone defect surface despite micro-movements of the defect walls. Aim 4 will study properties of injectable premixed calcium phosphate cement pastes. Premixed CPC pastes have the advantages that they are stable in the package and harden only after delivery to the defect site where the non-aqueous liquid is replaced by water from the surrounding tissue. While premixed CPC is considerably easier to use and is injectable, its properties are quite different from the conventional CPCs. The hardening time, resistance to washout, and HA conversion of premixed pastes consisting of CPC powder and non-aqueous liquids, such as glycerin, will be studied. The Principal Investigator also proposes to determine mechanical properties of the hardened CPC pastes.
描述(改编自《调查者摘要》):一种磷酸钙 在这项研究项目下开发的水泥(CPC)于#年获得FDA批准 1996年用于人类颅骨缺陷修复应用,从而成为第一个 可供临床使用的同类材料。而CPC被显示为 在许多牙科和医疗应用中非常有用,而其他 材料并不起作用,体内研究结果表明,为了 要达到最佳效果,CPC应具有手感和体内特性 最适合于特定的临床应用。该计划的目标 拟议的研究是为了阐明水泥凝结反应的机理和 了解影响水泥的物理化学因素=搬运和 体内特性。提出了四个具体目标。目标1建议 了解控制四钙水解反应的因素 磷酸(TTCP)、α-磷酸三钙(α-TCP)、磷酸氢钙 二水磷酸二氢钙(DCPD)、无水磷酸氢钙(DCPA)和氢氧化钙。 这些磷酸钙盐是不同CPC的主要成分。 形成羟基磷灰石(HA)的一种或多种盐类的水解是 负责水泥的硬化。更好地理解 这些盐的每一种的水解反应将为 影响一些重要水泥性能的因素,包括 转化为HA,形成缺钙或化学计量比的HA, 结晶度HA等。有缺陷的或非化学计量比的被认为是 更容易被生物吸收。目的2提出研究水泥的溶解速度。 脱盐溶液中的产品,其离子组成模拟 破骨细胞产生的酸性环境。一个对偶常数合成 在报告期间开发了滴定系统用于测量 模拟酸化条件下磷酸钙生物材料的溶出速率 生理解决方案。首席调查员建议利用这一点 作为体外模型预测CPC和TO吸收率的技术 了解控制溶出度的因素。目标3建议研究 非硬性和可再吸收磷酸钙骨水泥的性能。实验 用于研究CPC和壳聚糖(一种生物相容性聚合物)的复合材料 形成自硬性、可生物吸收、非刚性的骨移植材料。 这些材料应该在许多应用程序中有用,在这些应用程序中 种植体能够保持稳定并牢固地附着在骨缺损面上 尽管缺陷壁有微小的移动。目标4将研究 可注射的预混磷酸钙水泥浆体。预混的CPC糊料具有 优点是它们在包装中稳定,只有在包装后才会变硬 向缺陷部位输送,其中非水液体被水取代 从周围组织中分离出来。虽然预混CPC更易于使用 并且是可注射的,它的性质与传统的 CPCS。预混料的硬化时间、耐冲刷性和HA转化率 由CPC粉末和非水液体(如甘油)组成的糊状物将 被研究。首席调查员还建议确定机械 硬化的CPC浆体的性能。

项目成果

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LAURENCE C. CHOW其他文献

LAURENCE C. CHOW的其他文献

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{{ truncateString('LAURENCE C. CHOW', 18)}}的其他基金

Properties and Applications of Fluoride-Calcium-Phosphate Complex
氟钙磷酸盐络合物的性质及应用
  • 批准号:
    7963780
  • 财政年份:
    2010
  • 资助金额:
    $ 19.3万
  • 项目类别:
Properties and Applications of Fluoride-Calcium-Phosphate Complex
氟钙磷酸盐络合物的性质及应用
  • 批准号:
    8078015
  • 财政年份:
    2010
  • 资助金额:
    $ 19.3万
  • 项目类别:
NANOSTRUCTURED BIOACTIVE MATERIALS
纳米结构生物活性材料
  • 批准号:
    7932544
  • 财政年份:
    2006
  • 资助金额:
    $ 19.3万
  • 项目类别:
NANOSTRUCTURED BIOACTIVE MATERIALS
纳米结构生物活性材料
  • 批准号:
    7575121
  • 财政年份:
    2006
  • 资助金额:
    $ 19.3万
  • 项目类别:
NANOSTRUCTURED BIOACTIVE MATERIALS
纳米结构生物活性材料
  • 批准号:
    7185074
  • 财政年份:
    2006
  • 资助金额:
    $ 19.3万
  • 项目类别:
NANOSTRUCTURED BIOACTIVE MATERIALS
纳米结构生物活性材料
  • 批准号:
    7034959
  • 财政年份:
    2006
  • 资助金额:
    $ 19.3万
  • 项目类别:
NANOSTRUCTURED BIOACTIVE MATERIALS
纳米结构生物活性材料
  • 批准号:
    7371128
  • 财政年份:
    2006
  • 资助金额:
    $ 19.3万
  • 项目类别:
CALCIUM PHOSPHATE BONE REPAIR MATERIALS
磷酸钙骨修复材料
  • 批准号:
    7078524
  • 财政年份:
    1996
  • 资助金额:
    $ 19.3万
  • 项目类别:
CALCIUM PHOSPHATE CEMENTS
磷酸钙水泥
  • 批准号:
    2701014
  • 财政年份:
    1996
  • 资助金额:
    $ 19.3万
  • 项目类别:
CALCIUM PHOSPHATE CEMENTS
磷酸钙水泥
  • 批准号:
    2897099
  • 财政年份:
    1996
  • 资助金额:
    $ 19.3万
  • 项目类别:

相似海外基金

Studies of Aqueous Carbonates-Bicarbonates; Interactions of Ions in Natural Water Modeling (Chemistry)
含水碳酸盐-碳酸氢盐的研究;
  • 批准号:
    8406557
  • 财政年份:
    1984
  • 资助金额:
    $ 19.3万
  • 项目类别:
    Continuing Grant
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