Properties and Applications of Fluoride-Calcium-Phosphate Complex

描述（由申请人提供）：我们提出研究新发现的氟化物-钙-磷酸盐（FCaP）复合物，其允许制备同时含有所有牙齿矿物离子的溶液组合物：氟化物、钙和磷酸盐，FCaP溶液可被触发以沉淀磷酸盐污染的氟化钙（下文缩写为CaF 2）或CaF 2和含F磷灰石（F-Ap）矿物。初步结果表明，使用FCaP开发更高疗效的F方案而不增加F剂量或使用更低的F剂量是可行的。为了实现这一目标，有必要更好地了解FCaP复合物本身。具体来说，稳定的FCaP可以存在的组成范围是什么？什么是FCaP的结构，什么因素使FCaP不稳定，导致沉淀？我们建议进行研究，旨在通过以下目的获得对这些问题的见解：目的1 -FCaP复合物的制备和表征下形成了广泛的解决方案组合物。目的2 -使FCaP复合物不稳定导致沉淀的因素和沉淀产物的表征。目的3 -在体外模型中由FCaP络合物溶液产生的F沉积的初步评价。该研究的成功结果可以为未来的研究开辟新的前沿，旨在提高F的防龋功效，同时降低F的强度，并且使用更安全，特别是对儿童。 公共卫生相关性：我们建议研究一种新发现的氟化物-钙-磷酸盐（FCaP）复合物，该复合物允许制备同时含有所需水平的所有牙齿矿物离子（氟化物、钙和磷酸盐）而不沉淀的溶液组合物。FCaP溶液可被触发以在口腔中沉淀F储库。拟议研究的成功结果可导致开发新的超有效口腔冲洗液、漱口液、凝胶和含氟磷酸钙矿化产品，产品中的氟强度较低，因此使用更安全。

DESCRIPTION (provided by applicant): We propose to study a newly discovered fluoride-calcium-phosphate (FCaP) complex that allows preparation of solution compositions simultaneously containing all there tooth mineral ions: fluoride, calcium, and phosphate, without precipitation The FCaP solutions can be triggered to precipitate phosphate-contaminated calcium fluoride (hereafter abbreviated as CaF2) alone or CaF2 and F-containing apatitic (F-Ap) minerals. Preliminary results showed the feasibility of using FCaP for developing higher efficacy F regimens without increasing the F dose, or with a lower F dose. In order to achieve this objective, it is necessary to obtain a better understanding of the FCaP complex itself. Specifically, what are the composition ranges in which stable FCaP can exist? What is the structure of FCaP, What are the factors that destabilize FCaP, leading to precipitation? We propose to conduct studies aimed at gaining insights into these questions through the following Aims: Aim 1 - Preparation and characterization of FCaP complex formed under a wide range of solution compositions. Aim 2 - Factors that destabilize FCaP complex leading to precipitation and characterization of the precipitation products. Aim 3 - Initial Evaluation of F deposition produced by FCaP complex solutions in an in vitro model. Successful outcome of the proposed research can open new frontiers of future research aimed at improving the anticaries efficacy of F while decreasing the F strength and is safer to used, especially for children. PUBLIC HEALTH RELEVANCE: We propose to study a newly discovered fluoride-calcium-phosphate (FCaP) complex that allows preparation of solution compositions that simultaneously contain desired levels of all there tooth mineral ions: fluoride, calcium, and phosphate, without precipitation. The FCaP solutions can be triggered to precipitate F reservoirs in the mouth. Successful outcome of the proposed research can lead to development of new ultra effective oral rinses, dentifrices, gels, and F-containing calcium phosphate remineralizing products with a lower F strength in the product, and therefore is safer to use.