Properties and Applications of Fluoride-Calcium-Phosphate Complex

描述（由申请人提供）：我们建议研究一种新发现的氟化物-磷酸钙（FCaP）复合物，它可以制备同时含有所有牙齿矿物离子：氟化物、钙和磷酸盐的溶液组合物，而不会沉淀。FCaP溶液可以被触发沉淀被磷酸盐污染的氟化钙（以下简称CaF2）或CaF2和含f的磷灰石（F-Ap）矿物。初步结果表明，在不增加F剂量或降低F剂量的情况下，利用FCaP开发更高疗效的F方案是可行的。为了实现这一目标，有必要更好地了解FCaP复合物本身。具体来说，稳定FCaP可以存在的成分范围是什么？FCaP的结构是什么？是什么因素使FCaP不稳定，导致降水？我们建议通过以下目标开展旨在深入了解这些问题的研究：目标1 -在多种溶液组成下形成的FCaP复合物的制备和表征。目标2 -导致沉淀的FCaP复合物不稳定的因素和沉淀产物的表征。目的3 -在体外模型中初步评估FCaP复合物溶液产生的F沉积。该研究的成功结果将为未来的研究开辟新的领域，旨在提高F的抗炎功效，同时降低F的强度，并使其更安全，特别是对儿童。

DESCRIPTION (provided by applicant): We propose to study a newly discovered fluoride-calcium-phosphate (FCaP) complex that allows preparation of solution compositions simultaneously containing all there tooth mineral ions: fluoride, calcium, and phosphate, without precipitation The FCaP solutions can be triggered to precipitate phosphate-contaminated calcium fluoride (hereafter abbreviated as CaF2) alone or CaF2 and F-containing apatitic (F-Ap) minerals. Preliminary results showed the feasibility of using FCaP for developing higher efficacy F regimens without increasing the F dose, or with a lower F dose. In order to achieve this objective, it is necessary to obtain a better understanding of the FCaP complex itself. Specifically, what are the composition ranges in which stable FCaP can exist? What is the structure of FCaP, What are the factors that destabilize FCaP, leading to precipitation? We propose to conduct studies aimed at gaining insights into these questions through the following Aims: Aim 1 - Preparation and characterization of FCaP complex formed under a wide range of solution compositions. Aim 2 - Factors that destabilize FCaP complex leading to precipitation and characterization of the precipitation products. Aim 3 - Initial Evaluation of F deposition produced by FCaP complex solutions in an in vitro model. Successful outcome of the proposed research can open new frontiers of future research aimed at improving the anticaries efficacy of F while decreasing the F strength and is safer to used, especially for children. PUBLIC HEALTH RELEVANCE: We propose to study a newly discovered fluoride-calcium-phosphate (FCaP) complex that allows preparation of solution compositions that simultaneously contain desired levels of all there tooth mineral ions: fluoride, calcium, and phosphate, without precipitation. The FCaP solutions can be triggered to precipitate F reservoirs in the mouth. Successful outcome of the proposed research can lead to development of new ultra effective oral rinses, dentifrices, gels, and F-containing calcium phosphate remineralizing products with a lower F strength in the product, and therefore is safer to use.