Properties and Applications of Fluoride-Calcium-Phosphate Complex

描述(由申请人提供)：我们建议研究一种新发现的氟化物-钙-磷酸盐(FCAP)复合体，该复合体可以制备同时包含所有三种牙齿矿物离子：氟化物、钙和磷酸盐的溶液组合物，而无需沉淀，FCAP溶液可以被触发以单独沉淀受磷酸盐污染的氟化钙(以下简称CaF2)或含CaF2和F的磷灰石(F-AP)矿物。初步结果表明，在不增加F剂量或低F剂量的情况下，使用FCAP开发更有效的F方案是可行的。为了实现这一目标，有必要更好地了解FCAP复合体本身。具体地说，稳定的FCAP可以存在的组成范围是什么？FCAP的结构是什么？有哪些因素破坏了FCAP的稳定，导致降水？我们建议通过以下目标进行研究，以深入了解这些问题：目标1-在广泛的溶液组成下形成的FCAP络合物的制备和表征。目的2-影响FCAP络合物稳定性的因素及沉淀产物的表征。目的3-在体外模型中初步评价FCAP复合溶液产生的氟沉积。这项研究的成功结果可以为未来旨在提高氟化物防腐效果的研究开辟新的前沿，同时降低氟化物的强度，使用起来更安全，特别是对儿童。 公共卫生相关性：我们建议研究一种新发现的氟化物-钙-磷酸盐(FCAP)复合体，该复合体可以制备同时包含所需水平的所有牙齿矿物离子：氟化物、钙和磷酸盐的溶液组合物，而不需要沉淀。FCAP溶液可以被触发以在口中沉淀F储层。拟议研究的成功结果可以导致开发新的超有效口腔漱口水、牙膏、凝胶和含氟磷酸钙再矿化产品，产品中的F强度较低，因此使用起来更安全。

DESCRIPTION (provided by applicant): We propose to study a newly discovered fluoride-calcium-phosphate (FCaP) complex that allows preparation of solution compositions simultaneously containing all there tooth mineral ions: fluoride, calcium, and phosphate, without precipitation The FCaP solutions can be triggered to precipitate phosphate-contaminated calcium fluoride (hereafter abbreviated as CaF2) alone or CaF2 and F-containing apatitic (F-Ap) minerals. Preliminary results showed the feasibility of using FCaP for developing higher efficacy F regimens without increasing the F dose, or with a lower F dose. In order to achieve this objective, it is necessary to obtain a better understanding of the FCaP complex itself. Specifically, what are the composition ranges in which stable FCaP can exist? What is the structure of FCaP, What are the factors that destabilize FCaP, leading to precipitation? We propose to conduct studies aimed at gaining insights into these questions through the following Aims: Aim 1 - Preparation and characterization of FCaP complex formed under a wide range of solution compositions. Aim 2 - Factors that destabilize FCaP complex leading to precipitation and characterization of the precipitation products. Aim 3 - Initial Evaluation of F deposition produced by FCaP complex solutions in an in vitro model. Successful outcome of the proposed research can open new frontiers of future research aimed at improving the anticaries efficacy of F while decreasing the F strength and is safer to used, especially for children. PUBLIC HEALTH RELEVANCE: We propose to study a newly discovered fluoride-calcium-phosphate (FCaP) complex that allows preparation of solution compositions that simultaneously contain desired levels of all there tooth mineral ions: fluoride, calcium, and phosphate, without precipitation. The FCaP solutions can be triggered to precipitate F reservoirs in the mouth. Successful outcome of the proposed research can lead to development of new ultra effective oral rinses, dentifrices, gels, and F-containing calcium phosphate remineralizing products with a lower F strength in the product, and therefore is safer to use.