Properties and Applications of Fluoride-Calcium-Phosphate Complex

氟钙磷酸盐络合物的性质及应用

• 批准号: 7963780
• 负责人: LAURENCE C. CHOW
• 金额: $ 18.75万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7963780
• 关键词: Apatites; Binding; Calcium Fluoride; Chemicals; Chemistry; Child; Citrates; Clinical; Complex; Dental Enamel; Dentifrices; Deposition; Development; Diphosphates; Dose; Drug Formulations; Evaluation; Exposure to; Fluoride Ion; Fluorides; Future; Gel; Human; In Situ; In Vitro; Ionic Strengths; Ions; Lead; Measurement; Measures; Methods; Minerals; Modeling; Nature; Oral; Oral cavity; Outcome; Phase; Precipitation; Preparation; Process; Property; Regimen; Research; Saliva; Solutions; Source; Structure; Surface; Titrations; Tooth structure; Topical application; Water; anticaries; base; calcium phosphate; demineralization; design; frontier; improved; in vitro Model; in vivo; inhibitor/antagonist; inorganic phosphate; insight; public health relevance; remineralization

DESCRIPTION (provided by applicant): We propose to study a newly discovered fluoride-calcium-phosphate (FCaP) complex that allows preparation of solution compositions simultaneously containing all there tooth mineral ions: fluoride, calcium, and phosphate, without precipitation The FCaP solutions can be triggered to precipitate phosphate-contaminated calcium fluoride (hereafter abbreviated as CaF2) alone or CaF2 and F-containing apatitic (F-Ap) minerals. Preliminary results showed the feasibility of using FCaP for developing higher efficacy F regimens without increasing the F dose, or with a lower F dose. In order to achieve this objective, it is necessary to obtain a better understanding of the FCaP complex itself. Specifically, what are the composition ranges in which stable FCaP can exist? What is the structure of FCaP, What are the factors that destabilize FCaP, leading to precipitation? We propose to conduct studies aimed at gaining insights into these questions through the following Aims: Aim 1 - Preparation and characterization of FCaP complex formed under a wide range of solution compositions. Aim 2 - Factors that destabilize FCaP complex leading to precipitation and characterization of the precipitation products. Aim 3 - Initial Evaluation of F deposition produced by FCaP complex solutions in an in vitro model. Successful outcome of the proposed research can open new frontiers of future research aimed at improving the anticaries efficacy of F while decreasing the F strength and is safer to used, especially for children. PUBLIC HEALTH RELEVANCE: We propose to study a newly discovered fluoride-calcium-phosphate (FCaP) complex that allows preparation of solution compositions that simultaneously contain desired levels of all there tooth mineral ions: fluoride, calcium, and phosphate, without precipitation. The FCaP solutions can be triggered to precipitate F reservoirs in the mouth. Successful outcome of the proposed research can lead to development of new ultra effective oral rinses, dentifrices, gels, and F-containing calcium phosphate remineralizing products with a lower F strength in the product, and therefore is safer to use.

描述（由申请人提供）：我们建议研究一种新发现的氟化物-钙-磷酸盐（FCaP）复合物，该复合物允许制备同时含有所有牙齿矿物离子：氟化物、钙和磷酸盐的溶液组合物，而不发生沉淀。FCaP溶液可以被触发以沉淀磷酸盐污染的氟化钙（以下缩写为CaF2）单独或CaF2 和含氟磷灰石（F-Ap）矿物。初步结果表明，在不增加 F 剂量或降低 F 剂量的情况下，使用 FCaP 开发更高效的 F 方案是可行的。为了实现这一目标，有必要更好地了解 FCaP 复合体本身。具体来说，稳定的FCaP可以存在的成分范围是多少？ FCaP的结构是什么，哪些因素会破坏FCaP的稳定性，导致沉淀？我们建议进行研究，旨在通过以下目标深入了解这些问题： 目标 1 - 在各种溶液成分下形成的 FCaP 复合物的制备和表征。目标 2 - 导致 FCaP 复合物不稳定的因素，导致沉淀和沉淀产物的表征。目标 3 - 在体外模型中初步评估 FCaP 复合溶液产生的 F 沉积。拟议研究的成功结果可以开辟未来研究的新领域，旨在提高 F 的防龋功效，同时降低 F 的强度，并且使用起来更安全，尤其是对于儿童。 公共健康相关性：我们建议研究一种新发现的氟化物-钙-磷酸盐 (FCaP) 复合物，该复合物可以制备同时含有所需水平的所有牙齿矿物质离子（氟化物、钙和磷酸盐）的溶液组合物，而不会产生沉淀。 FCaP 溶液可被触发以沉淀口腔中的 F 储库。拟议研究的成功结果可以促进新型超有效口腔冲洗剂、牙粉、凝胶和含氟磷酸钙再矿化产品的开发，产品中氟强度较低，因此使用起来更安全。