NANOSTRUCTURED BIOACTIVE MATERIALS

纳米结构生物活性材料

• 批准号: 7034959
• 负责人: LAURENCE C. CHOW
• 金额: $ 21.38万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7034959
• 关键词: calcium; clinical research; dentin; heat; model; particle; phosphates; reduction; solutions; solvents

DESCRIPTION (provided by applicant): Nano forms of hydroxyapatite, other calcium phosphate compounds, and additional bioactive inorganic materials will be prepared by a newly developed method, employing either a spray drying or a flame pyrolysis technique in such a way that (1) target particle sizes over a wide range can be obtained, (2) compounds with both low and high solubilities can be prepared, and (3) the prepared particles would not be exposed to any solution environment after their formation and therefore would retain their original, highly reactive surfaces (Aim 1). Due to their small sizes and high reactivity, the prepared nano materials are expected to have a range of clinical applications. Two of which will be evaluated in Aims 2 and 3. Aim 2 will focus on evaluating the effectiveness of nano forms calcium fluoride (CaF2) as the source of fluoride (F) for remineralizing tooth enamel carious lesions using (1) an in vitro model to understand the relationship between CaF2 particle size and F deposition, (2) an in vivo saliva and plaque model to compare oral F retention produced by the nano CaF2 and currently used NaF rinses, and (3) an in situ demineralization/remineralization model to evaluate the remineralization effects of the nano CaF2 rinse. Aim 3 will evaluate the effectiveness of nano sized calcium phosphates and calcium fluoride in reducing dentin permeability, a property closely associated with dental hypersensitivity.

描述（由申请人提供）：纳米形式的羟基磷灰石、其他磷酸钙化合物和其他生物活性无机材料将通过一种新开发的方法制备，采用喷雾干燥或火焰热解技术，以这种方式(1)可以获得大范围的目标粒径，(2)可以制备低和高溶解度的化合物，(3)制备的颗粒在形成后不会暴露在任何溶液环境中，因此会保留其原始的、高度活性的表面（目标1）。由于其体积小，反应性高，所制备的纳米材料有望具有广泛的临床应用。其中两个将在目标2和目标3中进行评估。