PSYCHOBIOLOGICAL/GENETIC ANALYSIS OF AVOIDANCE LEARNING

回避学习的心理生物学/遗传学分析

• 批准号: 2033617
• 负责人: F ROBERT BRUSH
• 金额: $ 10.96万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2033617
• 关键词: GABA receptor; adrenal glands; adrenocorticotropic hormone; amygdala; avoidance behavior; behavioral /social science research tag; behavioral genetics; corticosterone; diazepam; ethology; gamma aminobutyrate; gene expression; genetic strain; high performance liquid chromatography; hippocampus; hormone regulation /control mechanism; inbreeding; laboratory rat; learning; psychobiology; steroid hormone biosynthesis; tranquilizer; water drinking behavior

This research is aimed at identifying the causal status of the genetic determinants and correlates of rats that have been selectively bred for good and poor avoidance learning. It will also examine whether or not there are genetic differences in ACTH release or in the synthesis of corticosterone using HPLC methods to separate the steroids. Implantable osmostic pumps will be used to manipulate the prenatal endocrine environment of animals of the two strains to determine whether the steroids mediate the expression of the gene(s) that control(s) the avoidance phenotypes and their correlates. Limbic structures will also be examined to identify differences in morphometry and in neurotransmitters, again using HPLC methods to separate the biogenic amines. In addition, three behavioral paradigms that are accepted as sensitive to anxiety will be used to study the effects of anxiolytic drugs that bind to the GABA-BZP receptor systems of the brain.

这项研究的目的是确定遗传因素的因果关系， 决定因素和相关的大鼠已被选择性地饲养， 好的和差的回避学习。 它还将审查是否 在促肾上腺皮质激素的释放或合成方面存在遗传差异， 皮质酮，使用HPLC方法分离类固醇。 可植入 体外泵将被用于控制产前内分泌 环境的动物，以确定是否 类固醇介导了控制类固醇的基因的表达。 回避表型及其相关性。 边缘结构也会 进行检查，以确定形态测量学和 神经递质，再次使用HPLC方法分离生物源性 胺。 此外，三种行为范式被认为是 对焦虑敏感的人将被用来研究抗焦虑药的作用 与大脑的GABA-BZP受体系统结合的药物。

项目成果

Running-wheel avoidance learning in rats (Rattus norvegicus): effects of contingencies and comparisons of different strains.

大鼠（褐家鼠）的跑轮回避学习：意外事件的影响和不同品系的比较。

• DOI: 10.1037/0735-7036.102.4.350
• 发表时间: 1988
• 期刊: Journal of comparative psychology (Washington, D.C. : 1983)
• 作者: Iso,H;Brush,FR;Fujii,M;Shimazaki,M
• 通讯作者: Shimazaki,M

Conditioned taste and taste-potentiated odor aversions in the Syracuse high- and low-avoidance (SHA/Bru and SLA/Bru) strains of rats (Rattus norvegicus).

雪城高和低回避（SHA/Bru 和 SLA/Bru）品系大鼠（褐家鼠）的条件性味觉和味觉增强的气味厌恶。

• DOI: 10.1037/0735-7036.106.3.248
• 发表时间: 1992
• 期刊: Journal of comparative psychology (Washington, D.C. : 1983)
• 作者: vonKluge,S;Brush,FR
• 通讯作者: Brush,FR

How do rats cope with the two-way escape problem in a homogeneous shuttle box?

老鼠如何应对同质穿梭箱中的双向逃逸问题？

• DOI: 10.55782/ane-1999-1305
• 发表时间: 1999
• 期刊: Acta neurobiologiae experimentalis
• 影响因子: 1.4
• 作者: Savonenko,AV;Brush,FR;Zieliński,K
• 通讯作者: Zieliński,K

Adrenal morphometry in unilateral and sham adrenalectomized Syracuse high and low avoidance rats.

单侧和假肾上腺切除的雪城高和低回避大鼠的肾上腺形态测定。

• DOI: 10.1016/0031-9384(90)90317-w
• 发表时间: 1990
• 期刊: Physiology & behavior
• 影响因子: 2.9
• 作者: DelPaine,SN;Brush,FR
• 通讯作者: Brush,FR

A selective genetic analysis of the Syracuse high- and low-avoidance (SHA/Bru and SLA/Bru) strains of rats (Rattus norvegicus).

对雪城高和低回避（SHA/Bru 和 SLA/Bru）品系大鼠（褐家鼠）的选择性遗传分析。

• DOI: 10.1016/s0166-4328(99)00075-3
• 发表时间: 1999
• 期刊: Behavioural brain research
• 影响因子: 2.7
• 作者: Brush,FR;Gendron,CM;Isaacson,MD
• 通讯作者: Isaacson,MD