INTERGROUP CPRU--FDR SCREENING IN 3 CA SITES/BREAST

本提案是根据RFA CSA-94-009提交的： 癌症预防合作研究单位。 的总体目标 建议的癌症预防研究单位（CPRU）是设计，实施 并评估标准化的电话教育和咨询 采取干预措施，促进适当的“共识批准”癌症筛查 癌症患者一级亲属的行为。 如果 将努力传播这一信息， （通过CPRU执行委员会）在三个最大的 美国的临床合作团体（即，东部 合作肿瘤组，西南肿瘤组，和北 中央癌症治疗组）。 这三个合作组织 将是本次CPRU的重要合作者。 组件项目 本文提出的（项目1）专门针对一级亲属 乳腺癌患者（即，母亲、姐妹篇和女儿）。 其他 该CPRU的组成项目将针对以下人员的一级亲属 结肠癌（项目2）和黑色素瘤（项目3）患者。 将接触参与机构的乳腺癌患者 在他们的一次诊所访问中，他们将被要求允许 联系符合年龄条件的女性一级亲属（40岁以上）。 拟议的电话咨询干预将是理论驱动的， 依靠互动障碍咨询结合后续邮件 以加强10-15分钟的咨询会议。 干预将是 使用随机化两组设计（干预与对照）进行评价 （基线时每组入组n=580名一级亲属）; 在3个月和12个月时进行电话随访。 CPRU将 由三个示例性共享资源（管理、电话 咨询和调查方法，以及数据管理和生物统计学）。 作为 在CPRU RFA中指示，这些共享资源中的每一个都在 更多细节见本申请的第8.5节。 的预算 行政共享资源与数据管理和生物统计 共享资源包含在此组件项目中。

This proposal is being submitted in response to RFA CSA-94-009: Collaborative Cancer Prevention Research Units. The overall goal of the proposed Cancer Prevention Research Unit (CPRU) is to design, implement and evaluate a standardized telephone-based education and counseling intervention to promote appropriate "consensus approved" cancer screening behavior among the first-degree relatives of selected cancer patients. If shown to be effective, efforts will be made to disseminate this intervention (via the CPRU Executive Committee) within three of the largest clinical cooperative groups in the United States (i.e., the Eastern Cooperative Oncology Group, the Southwest Oncology Group, and the North Central Cancer Treatment Group). All three of these cooperative groups will be substantial collaborators in this CPRU. The component project proposed herein (Project 1) specifically targets the first-degree relatives of breast cancer patients (i.e., mothers, sisters, and daughters). Other component projects in this CPRU will target the first-degree relatives of colon cancer (Project 2) and melanoma (Project 3) patients. Breast cancer patients at participating institutions will be approached during one of their clinic visits; they will be asked for permission to contact the age-eligible female first-degree relatives (40+ years of age). The proposed telephone counseling intervention will be theory-driven and rely on interactive barriers counseling combined with a follow-up mailout to reinforce the 10-15 minute counseling session. The intervention will be evaluated using a randomized two-group design (intervention vs control) (n=580 first-degree relatives per group enrolled at baseline); with telephone follow-up interviews scheduled at 3 and 12 months. The CPRU will be supported by three exemplary shared resources (Administration, Telephone Counseling and Survey Methods, and Data Management and Biostatistics). As instructed in the CPRU RFA, each of these shared resources is described in greater detail in Section 8.5 of this application. The budget for the Administrative Shared Resource and the Data Management and Biostatistical Shared Resource is included within this component project.