INTERGROUP CPRU--FDR SCREENING IN 3 CA SITES/BREAST

本提案是根据RFA CSA-94-009提交的： 癌症预防研究协作组。该计划的总体目标 拟议的癌症预防研究股(CPRU)将设计、实施 并评估标准化的电话教育和咨询 促进适当的“共识批准”癌症筛查的干预措施 选定癌症患者的一级亲属的行为。如果 被证明是有效的，将努力传播这一点 (通过CPRU执行委员会)在三个最大的 美国的临床合作小组(即东区 合作肿瘤学小组、西南肿瘤学小组和北方 中央癌症治疗组)。所有这三个合作小组 将是CPRU的重要合作者。组件项目 本方案(方案一)专门针对一级亲属 乳腺癌患者(即母亲、姐妹和女儿)。其他 这个CPRU中的组件项目将针对 结肠癌(项目2)和黑色素瘤(项目3)患者。 将与参与机构的乳腺癌患者进行接触。 在他们的一次诊所访问中；他们将被要求允许 联系符合年龄条件的女性一级亲属(40岁以上)。 拟议的电话咨询干预将是理论驱动的， 依靠互动障碍咨询和后续邮寄相结合 以加强10-15分钟的咨询会议。干预措施将是 采用随机两组设计进行评估(干预与对照) (n=基线登记的每组580名一级亲属)； 电话随访计划在3个月和12个月进行。CPRU将 由三个典型的共享资源(管理、电话)提供支持 咨询和调查方法、数据管理和生物统计学)。AS 根据CPRU RFA的说明，这些共享资源中的每一个都在中进行了描述 更详细的信息请参见本申请的第8.5节。这项计划的预算 行政共享资源与数据管理和生物统计学 共享资源包含在此组件项目中。

This proposal is being submitted in response to RFA CSA-94-009: Collaborative Cancer Prevention Research Units. The overall goal of the proposed Cancer Prevention Research Unit (CPRU) is to design, implement and evaluate a standardized telephone-based education and counseling intervention to promote appropriate "consensus approved" cancer screening behavior among the first-degree relatives of selected cancer patients. If shown to be effective, efforts will be made to disseminate this intervention (via the CPRU Executive Committee) within three of the largest clinical cooperative groups in the United States (i.e., the Eastern Cooperative Oncology Group, the Southwest Oncology Group, and the North Central Cancer Treatment Group). All three of these cooperative groups will be substantial collaborators in this CPRU. The component project proposed herein (Project 1) specifically targets the first-degree relatives of breast cancer patients (i.e., mothers, sisters, and daughters). Other component projects in this CPRU will target the first-degree relatives of colon cancer (Project 2) and melanoma (Project 3) patients. Breast cancer patients at participating institutions will be approached during one of their clinic visits; they will be asked for permission to contact the age-eligible female first-degree relatives (40+ years of age). The proposed telephone counseling intervention will be theory-driven and rely on interactive barriers counseling combined with a follow-up mailout to reinforce the 10-15 minute counseling session. The intervention will be evaluated using a randomized two-group design (intervention vs control) (n=580 first-degree relatives per group enrolled at baseline); with telephone follow-up interviews scheduled at 3 and 12 months. The CPRU will be supported by three exemplary shared resources (Administration, Telephone Counseling and Survey Methods, and Data Management and Biostatistics). As instructed in the CPRU RFA, each of these shared resources is described in greater detail in Section 8.5 of this application. The budget for the Administrative Shared Resource and the Data Management and Biostatistical Shared Resource is included within this component project.