CIS Research Consortium (CISRC): Years 2006-2011

描述(由申请人提供)：在这项癌症信息服务联盟(CISRC)计划项目赠款的竞争性续签中，将测试两种健康沟通干预措施在三组致电癌症信息服务(1-800-4-癌症)的癌症患者中的有效性：新诊断的前列腺癌(项目1)和乳腺癌(项目2)患者，以及重新进入项目的乳腺癌患者(项目3)。这两项干预措施包括：1)创新和高度互动的多媒体程序；2)由独联体信息专家进行的同样创新的电话回电干预。这两种干预措施都有一个共同的主题，即帮助这三个目标人群为他们正在进行的癌症经历做准备(例如，癌症治疗决策和治疗准备，项目1和2；乳腺癌后生活，项目3)。在报告在基线时使用计算机的登记参与者中，所有项目将采用相同的随机三组阶梯式设计，其中：组1=日常服务(+)标准印刷材料；组2=组1(+)多媒体节目；组3=组2(+)7天随访时的CIS电话回拨干预访谈。在未按基线报告使用计算机的登记参与者中，所有项目将采用相同的两组设计，该设计将根据未来的随机试验作为可行性研究进行，其中组1A=与上文第1组相同；组2A=组1A(+)独联体回拨干预面谈。假设驱动的调解和结果分析将基于2个月、6个月和12个月随访的电话采访。创新的跨项目探索性分析也被提出用于一套核心的共享结果资源，这将是第一次在癌症生存连续性的延长部分进行此类分析。这是对先前申请的重新提交，该申请因前一审查委员会的关切而进行了几次修订，大大受益于该申请。支持每个项目的核心资源如下：行政核心、干预发展和测量核心(IDMC)、调查方法核心(SMC)和生物统计核心(BC)。通过与独联体所有地区呼叫中心的合作，中国癌症信息中心将在全国动员首屈一指的癌症信息计划，拥有前所未有的机会，以充分的统计力量同时进行这三项试验，并具有巨大的传播潜力。

DESCRIPTION (provided by applicant): In this competitive renewal of the Cancer Information Service Consortium (CISRC) program project grant, two health communication interventions will be tested for efficacy across three groups of cancer patients who call the Cancer Information Service (1-800-4-CANCER): newly diagnosed prostate (Project 1) and breast (Project 2) cancer patients, and breast cancer patients at re-entry (Project 3). These two interventions include: 1) an innovative and highly interactive multimedia program, and 2) an equally innovative telephone callback intervention conducted by CIS Information Specialists. Both interventions share the common theme of helping these three target populations prepare for their on-going cancer experience (e.g. cancer-treatment decision-making and preparation for treatment, Projects 1 and 2; life after breast cancer, Project 3). Among enrolled participants who report access to a computer at baseline, all projects will share the same randomized three-group stepped design, where: Group 1 = usual service (+)standard print material; Group 2 = Group 1 (+) multimedia program; and Group 3 = Group 2 (+) a CIS telephone callback intervention interview at 7 days follow-up. Among enrolled participants who do not report access to a computer at baseline, all projects will share the same two-group design that will be conducted as a feasibility study pursuant to a future randomized trial, where Group 1A = same as Group 1above; Group 2A = Group 1A (+) a CIS callback intervention interview. Hypothesis-driven mediational and outcome analyses will be based on telephone interviews at 2-, 6-, and 12-months follow-up. Innovative cross-project exploratory analyses are also proposed for a core set of shared outcome resources, which will be the first of their kind across an extended segment of the cancer survivorship continuum. This is a resubmission of an earlier application that has benefited greatly from several revisions prompted by the concerns of the previous review committee. Supporting each project will be the following core resources: Administrative Core, Intervention Development and Measurement Core (IDMC), Survey Methods Core (SMC), and the Biostatistical Core (BC). By collaborating with all regional call centers of the CIS, the CISRC will mobilize the premiere cancer information program in the nation, with an unprecedented opportunity to conduct these three trials simultaneously with ample statistical power, and with significant potential for dissemination.