SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS

说明：在本更新提案中， 本研究的目的是为 有机化学和医学通过合成研究 生理活性天然和人造有机化合物，包括 1.海葵毒素：全合成，优选的局部和整体构象， 放射性标记的PTX的制备和亲和层析的制备 列，2.人血中C-和O-糖苷的构象分析 抗原，含脂多糖的6-O-甲基-D-葡萄糖（MGLP）和 含3-O-甲基甘露糖的多糖（MMP）和C-海藻糖， 3.化学标尺：脂肪酸及其衍生物的构象分析 含离子有机大分子的设计与合成 类螺旋藻组装体; Maitotoxin的立体化学归属，4。 AAL毒素和伏马菌素的结构解析和合成，5. Ni（II）/Cr（II）介导的偶联反应：不对称过程，6. 三足配体化学：肠杆菌素类似物和其他，和7. 蟾毒和Aranotin的全合成。 校长 研究人员指出，有机化学的力量是最 通过挑战复杂的系统有效地扩展， 医学的进步关键取决于权力的扩展 有机化学。 他进一步指出，这也是他的具体做法。 目的开发实用和有效的合成某些 具有高生理活性的天然产物及其类似物 活动，但不能从自然资源中获得可观的数量 源 他希望这些研究能够促进 药

DESCRIPTION: In this renewal proposal it is stated that the major objective in this research is to make significant contributions to organic chemistry and medicine through synthetic studies on physiologically active natural and man-made organic compounds, including 1. Palytoxin: Total Synthesis, Preferred Local and Global Conformation, Preparation of Radioactively Labelled PTX, and Preparation of Affinity Column, 2. Conformational Analysis of C- and O- Glycosides: Human Blood antigens, 6-O-Methyl-D-glucose containing Lipopolysaccharides (MGLP) and 3-O-methylmannose-containing Polysaccharides (MMP), and C-Trehaloses, 3. Chemical Ruler: Conformational Analysis of Fatty Acids and Their Derivatives; Design and Synthesis of Large Organic Molecules with Ion Channel-like Assemblies; Stereochemistry Assignment of Maitotoxin, 4. Structure Elucidation and Synthesis of AAL toxins and Fumonisins, 5. Ni(II)/Cr(II)-Mediated Coupling Reaction: Asymmetric Process, 6. Tripodal Ligand Chemistry: Enterobactin analogs and others, and 7. Total Synthesis of Batrachotoxin and Aranotin. The principal investigator notes that the power of organic chemistry is most effectively extended by challenging complex systems, and much of the progress of medicine critically depends upon the extension of the power of organic chemistry. He further states that it is also his specific objective to develop practical and efficient syntheses of certain natural products and their analogs which have high physiological activity, but are not available in appreciable amounts from natural sources. He expects that these studies are to stimulate progress in medicine.