SYNTHETIC STUDIES TOWARDS TAXOL AND RELATED COMPOUNDS
SYNTHETIC STUDIES TOWARDS TAXOL AND RELATED COMPOUNDS
批准号:
3199607
负责人:
YOSHITO KISHI
金额:
$8.39万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1991
资助国家:
美国
项目状态:
已结题
起止时间:
1991-07-01 至 1995-04-30
中文摘要
本研究的主要目的是使
英文摘要
The major objective of this research is to make significant
contributions to organic chemistry and medicine through synthetic studies
towards the taxane class of natural products, specifically focused on the
antitumor alkaloid taxol. Our research efforts will be focused on the
development of a practical, general, and flexible total synthesis of
taxol for two purposes: (1) to secure a large scale supply of taxol or
the most effective taxol analogue for clinical use and (2) to provide a
wide variety of taxol analogues for structure/activity studies in order
to identify the most effective taxol analogue. Experimentally, we plan
to construct the ring B of taxol at the very late stage of synthesis by
using the Ni(II)/Cr(Il)-mediated coupling reaction in a simultaneous or
step-wise manner. Obvious advantages of this approach include a high
degree of convergence and flexibility and a minimum number of steps
required for the functional group manipulation after the key coupling
reaction. By using a model system, we have demonstrated the feasibility
of this approach.
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专著(0)
科研奖励(0)
会议论文
MASS SPECTROMETER FOR LC/MS
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批准号:2283874
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项目类别:
-
资助金额:$22.83万
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财政年份:1995
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负责人:YOSHITO KISHI
-
依托单位:
SYNTHETIC STUDIES TOWARDS TAXOL AND RELATED COMPOUNDS
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批准号:2096359
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项目类别:
-
资助金额:$8.55万
-
财政年份:1991
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHETIC STUDIES TOWARDS TAXOL AND RELATED COMPOUNDS
-
批准号:3199606
-
项目类别:
-
资助金额:$8.07万
-
财政年份:1991
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHETIC STUDIES TOWARDS TAXOL AND RELATED COMPOUNDS
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批准号:3199605
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项目类别:
-
资助金额:$7.07万
-
财政年份:1991
-
负责人:YOSHITO KISHI
-
依托单位:
HIGH RESOLUTION AND ROUTINE SERVICE MASS SPECTROMETERS
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批准号:3521312
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项目类别:
-
资助金额:$40.0万
-
财政年份:1991
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
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批准号:2431108
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项目类别:
-
资助金额:$60.62万
-
财政年份:1978
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负责人:YOSHITO KISHI
-
依托单位:
SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
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批准号:2633710
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项目类别:
-
资助金额:$41.79万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
-
批准号:3165775
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项目类别:
-
资助金额:$20.08万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHESIS OF ANTITUTMOR NATURAL PRODUCTS
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批准号:3481913
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项目类别:
-
资助金额:$31.09万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
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批准号:6137377
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项目类别:
-
资助金额:$44.83万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
-
批准号:6626537
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项目类别:
-
资助金额:$48.93万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
-
批准号:3394717
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项目类别:
-
资助金额:$43.53万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
-
批准号:3394713
-
项目类别:
-
资助金额:$43.22万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
-
批准号:2697548
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项目类别:
-
资助金额:$43.55万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
-
批准号:2087022
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项目类别:
-
资助金额:$38.75万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
-
批准号:2087021
-
项目类别:
-
资助金额:$38.27万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHESIS OF ANTITUTMOR NATURAL PRODUCTS
-
批准号:3481912
-
项目类别:
-
资助金额:$29.88万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
-
批准号:6489019
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项目类别:
-
资助金额:$47.52万
-
财政年份:1978
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负责人:YOSHITO KISHI
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依托单位:
Synthesis of Antitumor Natural Products
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批准号:6920759
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项目类别:
-
资助金额:$46.52万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
-
批准号:2262385
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项目类别:
-
资助金额:$57.6万
-
财政年份:1978
-
负责人:YOSHITO KISHI
-
依托单位:
国内基金
海外基金
Iboga alkaloids骨架导向的不对称串联反应构建吖庚环并[4,5-b]吲哚及其在全合成中的应用
-
批准号:21801032
-
项目类别:青年科学基金项目
-
资助金额:26.0万元
-
批准年份:2018
-
负责人:陈惠渝
-
依托单位: