SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS

这项研究的主要目的是为 有机化学和医学，通过研究， 具有抗肿瘤活性或促肿瘤作用的天然产物的合成 活性，包括软海绵素，C-吲哚内酰胺V，细胞分裂素， 紫杉醇/三尖杉宁碱、霉烯酰胺/奥那酰胺和柔红霉素类似物。 我们 相信有机化学的力量，尤其是有机合成， 通过挑战复杂的系统， 医学的进步当然取决于医学力量的扩大。 化学. 更具体地说，将首先进行研究， 开发通用的，灵活的，有效的合成某些天然的 产物，然后将其应用于其类似物的合成， 衍生品，其研究将提供线索，发展更好地 抗肿瘤药物或了解肿瘤促进过程。 之间 在提出的五个项目中，软海绵素项目是最先进的， 我们对抗肿瘤药物的探索和研究计划被提交给 鉴定用于进一步临床开发的候选药物。

The major objective of this research is to make significant contributions to organic chemistry and medicine through studies directed towards the synthesis of natural products with antitumor activity or tumor-promoting activity, including halichondrins, C-indolactam V, cytoblastin, taxol/cephalomannine, mycalamides/onnamide, and daunomycin analogs. We believe that the power of organic chemistry, especially organic synthesis, is most effectively extended by challenging complex systems, and much of the progress of medicine certainly depends upon extension of the power of chemistry. More specifically, research efforts will be made first to develop general, flexible, and efficient syntheses of certain natural products and then to apply these to the synthesis of their analogs and derivatives, whose study will provide clues for developing better antitumor drugs or for understanding the tumor-promoting process. Among the five programs proposed, the halichondrin project is most advanced in our quest for an antitumor drug, and research plans are presented to identify a drug candidate for further clinical development.