SYNTHESIS OF ANTITUTMOR NATURAL PRODUCTS

这项研究的主要目标是做出重大贡献 有机化学和医学领域的研究 具有抗肿瘤活性或促癌活性的天然产物的合成 活性，包括柔红霉素-阿克拉霉素类似物，新霉素， 海藻毒素、刺杀毒素、二酰甘油类似物，以及 紫杉醇-头孢甘宁。我们相信有机化学的力量， 尤其是有机合成，最有效的扩展是通过挑战 复杂的系统，而医学的许多进步当然取决于 在扩展了化学的力量之后。更具体地说，研究 首先要努力发展通用性、灵活性、高效性 某些天然产物的合成，然后将这些应用于 它们的类似物和衍生物的合成，其研究将提供线索 为了开发更好的抗肿瘤药物或为了了解 促进肿瘤的过程。

The major objective of this research is to make significant contributions to organic chemistry and medicine through studies directed towards the synthesis of natural products with antitumor activity or tumor-promoter activity, including daunomycin-aclacinomycin analogs, nogalamycin, aplysiatoxins, teleocidins, diacylglycerol analogs, and taxol-cephalomannine. We believe that the power of organic chemistry, especially organic synthesis, is most effectively extended by challenging complex systems, and much of the progress of medicine certainly depends upon extension of the power of chemistry. More specifically, research efforts will be made first to develop general, flexible and efficient syntheses of certain natural products and then to apply these to the synthesis of their analogs and derivatives, whose study will provide clues for developing better antitumor drugs or for understanding the tumor-promoting process.