SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS

这项研究的主要目标是做出重大贡献 有机化学和医学领域的研究 具有抗肿瘤或促肿瘤活性的天然产物的合成 活性物质，包括灯盏花素、C-吲哚内酰胺V、细胞分裂素、 紫杉醇/头孢曼宁、豆蔻酰胺/翁那胺和柔红霉素类似物。我们 相信有机化学，特别是有机合成的力量， 是通过挑战复杂系统来最有效地扩展的，而且许多 医学的进步当然有赖于医学力量的扩展 化学反应。更具体地说，将首先进行研究工作，以 开发通用、灵活和高效的某些天然化合物的合成 然后将它们应用于合成它们的类似物和 衍生品，其研究将为更好地开发提供线索 抗肿瘤药物或了解肿瘤促进过程。其中 在提出的五个方案中，何首乌项目是最先进的 我们对抗肿瘤药物的追求和研究计划被提交给 确定用于进一步临床开发的候选药物。

The major objective of this research is to make significant contributions to organic chemistry and medicine through studies directed towards the synthesis of natural products with antitumor activity or tumor-promoting activity, including halichondrins, C-indolactam V, cytoblastin, taxol/cephalomannine, mycalamides/onnamide, and daunomycin analogs. We believe that the power of organic chemistry, especially organic synthesis, is most effectively extended by challenging complex systems, and much of the progress of medicine certainly depends upon extension of the power of chemistry. More specifically, research efforts will be made first to develop general, flexible, and efficient syntheses of certain natural products and then to apply these to the synthesis of their analogs and derivatives, whose study will provide clues for developing better antitumor drugs or for understanding the tumor-promoting process. Among the five programs proposed, the halichondrin project is most advanced in our quest for an antitumor drug, and research plans are presented to identify a drug candidate for further clinical development.