SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS

本研究的主要目的是使 通过合成对有机化学和医学的贡献 生理活性天然和人造有机 化合物，包括1。全合成和构象 海洋天然产物海葵毒素的分析; 2. 合成 寡糖及其碳的构象分析 类似物如纤维二糖、麦芽糖、人血型 抗原和蔗糖，3.合成及构象分析 半合成聚醚抗生素，4.的发展 有机溶剂可溶的310-螺旋寡肽，5.半 合成水母发光蛋白作为测定局部 完整细胞上的钙浓度，以及6.映选择 石房蛤毒素和gonyautoxins的合成。 我们认为 有机化学的力量是最有效地扩展， 挑战复杂的系统， 医学关键取决于权力的扩展， 有机化学 我们的具体目标也是开发实用高效的 某些天然产物及其类似物的合成， 具有较高的生理活性，但在 从自然资源中获得可观的数量。 这些研究再次 有望刺激医学的进步

The major objective in this research is to make significant contributions to organic chemistry and medicine through synthetic studies on physiologically active natural and man-made organic compounds, including 1. the total synthesis and conformational analysis of the marine natural product palytoxin, 2. the synthesis and conformational analysis of oligosaccharides and their carbon analogues such as cellobiose, maltose, human blood group antigens, and sucrose, 3. the synthesis and conformational analysis of semi-synthetic polyether antibiotics, 4. the development of organic solvent soluble 310-helical oligopeptides, 5. semi- synthetic aequorins as a tool of the determination of local calcium concentration on the intact cells, and 6. enantioselective synthesis of saxitoxins and gonyautoxins. We believe that the power of organic chemistry is most effectively extended by challenging complex systems, and much of the progress of medicine critically depends upon the extension of the power of organic chemistry. It is also our specific objective to develop practical and efficient syntheses of certain natural products and their analogues which have high physiological activity, but are not available in appreciable amount from natural sources. These studies are again expected to stimulate the progress in medicine.