PERSISTENCE AND CHANGE IN DRINKING HABITS--PROJECT TWO

饮酒习惯的坚持和改变——项目二

• 批准号: 2442162
• 负责人: ANDREW C. HEATH
• 金额: $ 48.8万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2442162
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; antisocial personality; anxiety disorders; behavioral /social science research tag; behavioral genetics; comorbidity; conduct disorder; disease /disorder proneness /risk; early experience; family genetics; family structure /dynamics; female; gender difference; genotype; health care service utilization; human data; human subject; interview; longitudinal human study; major depression; psychological stressor; psychosis; sex behavior; smoking; substance abuse related disorder; tobacco abuse; twin /multiplet

This revised competing continuation, focused on a cohort of young Australian twin pairs born 1964-1971, surveyed initially by mailed questionnaire in 1990-1992, seeks a further four years support for a study of the role of genetic and social factors, and their covariation and interaction, in the development and natural history of patterns of alcohol use, and of alcohol abuse and dependence, with a particular focus on alcohol problems and alcohol use in women. Telephone interviews will be conducted with some 4500 twins, to assess lifetime history of alcohol dependence and abuse (DSM-IIIR & IV), major depression and anxiety disorders, history of adolescent conduct problems smoking and illicit substance use, traumatic events and other early environmental experiences. Male like-ex and unlike-sex pairs, as well as female like-sex pairs, will be studied, in order to estimate the effects of genotype x gender interaction, and to maximize the precision of estimates of genetic contributions to alcoholism risk in women. Twelve month follow-up interviews will be conducted with pairs where at least one twin screened positive for alcohol dependence (either DSM-IIIR or IV) at stage 1, as well as with a small random sample of 100 male and 100 female unaffected twins. Additional assessments to be obtained at follow-up will include more detailed information about the time course and co-occurrence of problems with alcohol and other comorbid disorders; other substance dependence or abuse, anti-social personality disorder, somatization disorder, and history of oppositional-defiant problems; more detailed assessments of early environment; and measures of health-services utilization, economic and occupational status, and other variables that may be influenced by untreated alcohol problems. These data, together with interview data from an older cohort of twins surveyed by telephone during the current grant cycle (the 1981 cohort: N=6000 twins), and questionnaire data from both cohorts, will be used to test hypotheses about the pathways by which genetic and environmental influences on alcoholism risk arise, and the extent to which such influences vary as a function of gender and birth cohort.

这一修订后的竞争续集，重点放在一群年轻的 出生于1964-1971年的澳大利亚双胞胎，最初通过邮寄进行的调查 1990-1992年的调查问卷，要求为一项研究再提供四年的支持 遗传和社会因素的作用，以及它们的协变性和 酒精模式的发展和自然历史中的相互作用 以及酗酒和依赖的使用，特别注重 女性的酒精问题和酒精使用。电话采访将是 对大约4500对双胞胎进行了调查，以评估酒精的终生历史 依赖和虐待(DSM-IIIR&IV)、严重抑郁和焦虑 精神障碍、青少年行为问题史、吸烟和非法 物质使用、创伤事件和其他早期环境经历。 男性同性伴侣和异性伴侣，以及女性同性伴侣，将 进行研究，以评估基因x性别的影响 交互作用，并最大限度地提高遗传估计的精度 对女性酗酒风险的贡献。12个月随访 面试将与至少一对双胞胎中的一人进行筛选 酒精依赖(DSM-IIIR或IV)阶段1呈阳性，AS 以及100名男性和100名女性的随机小样本 双胞胎。将在后续行动中获得的其他评估包括 关于时间进程和共同发生的更详细的信息 酒精和其他共病障碍的问题；其他物质 依赖或虐待、反社会人格障碍、躯体化 无序和对抗问题的历史；更详细 早期环境评估；保健服务措施 利用率、经济和职业地位以及其他变量 可能受到未经治疗的酒精问题的影响。这些数据加在一起 通过电话调查了一群年龄较大的双胞胎的采访数据 在本赠款周期内(1981年队列：N=6000对双胞胎)，以及 来自两个队列的问卷数据将被用来检验假设 关于遗传和环境影响的途径 酒精中毒风险的出现，以及这种影响的程度随着 性别和出生队列的作用。