ALCOHOL USE DISORDER IN YOUNG WOMEN: GENETIC EPIDEMIOLOGY: MOAFTS WAVE 7

年轻女性酒精使用障碍：遗传流行病学：MOAFTS 第 7 波

• 批准号: 8317639
• 负责人: ANDREW C. HEATH
• 金额: $ 61.27万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8317639
• 关键词: 21 year old; Address; Adolescence; Adolescent; Adult; African American; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcoholism; Alcohols; Anxiety Disorders; Biological; Birth; Birth Records; Child; Childhood; Cohort Studies; Collection; Conflict (Psychology); Consent; Consumption; DNA; Data; Data Analyses; Data Collection; Deltastab; Dependence; Development; Diagnostic; Disadvantaged; Disease remission; Distal; Divorce; Education; Employment; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiology; Etiology; European; Failure; Family; Female; Female Adolescents; Forcible intercourse; Funding; General Population; Genes; Genetic; Genetic Determinism; Genetic Structures; Genetic Variation; Genotype; Goals; Grant; Heavy Drinking; Home environment; Hyperactive behavior; Impairment; Individual; Interview; Joints; Major Depressive Disorder; Marital separation; Marriage; Mediating; Mediator of activation protein; Missouri; Modeling; Molecular; National Institute of Child Health and Human Development; Oppositional Defiant Disorder; Outcome; Parenting behavior; Parents; Participant; Phenotype; Preparation; Preventive Intervention; Prospective Studies; Psychopathology; Recording of previous events; Recovery; Reporting; Reproduction; Research; Research Project Grants; Respondent; Risk; Role; Saliva; Sample Size; Sampling; Sexual abuse; Smoker; Smoking; Stepparent; Substance Use Disorder; Supervision; Surveys; Symptoms; Telephone; Testing; Time; Tobacco Dependence; Tobacco use; Trauma; Twin Multiple Birth; Twin Studies; alcohol misuse; alcohol related problem; alcohol risk; alcohol use disorder; base; cohort; college; consumption measures; depressive symptoms; drinking; follow-up; genetic epidemiology; high risk; inattention; informant; interpersonal conflict; offspring; parental alcoholism; peer; physical abuse; problem drinker; prospective; sample collection; sex; socioeconomics; transmission process; young adult; young woman

We propose a wave seven telephone diagnostic interview follow-up of the MOAFTS (Missouri Adolescent Female Twin Study) young cohorts A and B (target N=2100 twin interviews), and for some participants who have not yet provided samples, saliva sample collection (target N=840) for genotyping for zygosity confirmation. MOAFTS is a prospective study of a birth cohort of female like-sex twin pairs (N=370 African- American pairs, N=1999 European/Other Ancestry pairs) identified from birth records and first assessed in adolescence, at median age 16. Goals of the project are to characterize, in a broadly representative general population female twin cohort, gene-environment interplay in alcoholism and associated substance use disorders, focusing on (i) parental alcoholism and its associated twin offspring environmental risk-exposures and outcomes, and (ii) the development and course of female drinking and alcohol-related problems, as well as other substance use and problems (particularly tobacco use and dependence), through adolescence into young adulthood, emphasizing precursors/mediators and moderators of genetic and environmental effects on both onset of and recovery from problems. In the most recent data-collection, interviews were completed with approximately 3500 respondents at ages 21-30. Wave seven will provide a further follow-up of alcohol and other substance use and problems, and proximal environmental exposures, so that most twins are through their period of greatest risk for onset of alcohol problems, and the sample will be old enough to be informative about the predictors of remission versus persistence of alcohol problems and heavy drinking (target N=700 assessed at age 30, N=1400 assessed at age 28/N=100 new dependence cases). Our research is motivated by the concern that the genetic transmission of risks of alcohol and other substance use disorders frequently occurs in the context of high-risk environmental exposures commonly associated with parental alcoholism - including interpersonal conflict and divorce or never-cohabitation, step-parent presence, childhood assaultive trauma, family socioeconomic disadvantage - risks that need not be reduced by the departure of an alcoholic parent from the home. Through completion of the wave seven data-collection and data-analyses, our goals are to understand how these early environmental exposures, in combination with genetic effects, influence onset and course of heavy drinking and alcohol problems, either directly, or through effects on timing of onset of alcohol use and on comorbid substance use, and effects on subsequent adult role changes of the twins (early or delayed parenting; relationship formation, conflict and dissolution; education completion, employment, and adult peer relationships); and to identify other variables (history of childhood or adolescent-onset psychopathology, other substance use disorders) that may mediate or moderate these relationships. Current understanding of the genetic epidemiology of female alcohol use disorders is based largely on either retrospective or underpowered studies - a gap that the MOAFTS cohort will help to fill.

我们建议对密苏里州青少年进行第七波电话诊断访谈随访