ALCOHOL USE DISORDER IN YOUNG WOMEN: GENETIC EPIDEMIOLOGY: MOAFTS WAVE 7

年轻女性酒精使用障碍：遗传流行病学：MOAFTS 第 7 波

• 批准号: 8317639
• 负责人: ANDREW C. HEATH
• 金额: $ 61.27万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8317639
• 关键词: 21 year old; Address; Adolescence; Adolescent; Adult; African American; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcoholism; Alcohols; Anxiety Disorders; Biological; Birth; Birth Records; Child; Childhood; Cohort Studies; Collection; Conflict (Psychology); Consent; Consumption; DNA; Data; Data Analyses; Data Collection; Deltastab; Dependence; Development; Diagnostic; Disadvantaged; Disease remission; Distal; Divorce; Education; Employment; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiology; Etiology; European; Failure; Family; Female; Female Adolescents; Forcible intercourse; Funding; General Population; Genes; Genetic; Genetic Determinism; Genetic Structures; Genetic Variation; Genotype; Goals; Grant; Heavy Drinking; Home environment; Hyperactive behavior; Impairment; Individual; Interview; Joints; Major Depressive Disorder; Marital separation; Marriage; Mediating; Mediator of activation protein; Missouri; Modeling; Molecular; National Institute of Child Health and Human Development; Oppositional Defiant Disorder; Outcome; Parenting behavior; Parents; Participant; Phenotype; Preparation; Preventive Intervention; Prospective Studies; Psychopathology; Recording of previous events; Recovery; Reporting; Reproduction; Research; Research Project Grants; Respondent; Risk; Role; Saliva; Sample Size; Sampling; Sexual abuse; Smoker; Smoking; Stepparent; Substance Use Disorder; Supervision; Surveys; Symptoms; Telephone; Testing; Time; Tobacco Dependence; Tobacco use; Trauma; Twin Multiple Birth; Twin Studies; alcohol misuse; alcohol related problem; alcohol risk; alcohol use disorder; base; cohort; college; consumption measures; depressive symptoms; drinking; follow-up; genetic epidemiology; high risk; inattention; informant; interpersonal conflict; offspring; parental alcoholism; peer; physical abuse; problem drinker; prospective; sample collection; sex; socioeconomics; transmission process; young adult; young woman

We propose a wave seven telephone diagnostic interview follow-up of the MOAFTS (Missouri Adolescent Female Twin Study) young cohorts A and B (target N=2100 twin interviews), and for some participants who have not yet provided samples, saliva sample collection (target N=840) for genotyping for zygosity confirmation. MOAFTS is a prospective study of a birth cohort of female like-sex twin pairs (N=370 African- American pairs, N=1999 European/Other Ancestry pairs) identified from birth records and first assessed in adolescence, at median age 16. Goals of the project are to characterize, in a broadly representative general population female twin cohort, gene-environment interplay in alcoholism and associated substance use disorders, focusing on (i) parental alcoholism and its associated twin offspring environmental risk-exposures and outcomes, and (ii) the development and course of female drinking and alcohol-related problems, as well as other substance use and problems (particularly tobacco use and dependence), through adolescence into young adulthood, emphasizing precursors/mediators and moderators of genetic and environmental effects on both onset of and recovery from problems. In the most recent data-collection, interviews were completed with approximately 3500 respondents at ages 21-30. Wave seven will provide a further follow-up of alcohol and other substance use and problems, and proximal environmental exposures, so that most twins are through their period of greatest risk for onset of alcohol problems, and the sample will be old enough to be informative about the predictors of remission versus persistence of alcohol problems and heavy drinking (target N=700 assessed at age 30, N=1400 assessed at age 28/N=100 new dependence cases). Our research is motivated by the concern that the genetic transmission of risks of alcohol and other substance use disorders frequently occurs in the context of high-risk environmental exposures commonly associated with parental alcoholism - including interpersonal conflict and divorce or never-cohabitation, step-parent presence, childhood assaultive trauma, family socioeconomic disadvantage - risks that need not be reduced by the departure of an alcoholic parent from the home. Through completion of the wave seven data-collection and data-analyses, our goals are to understand how these early environmental exposures, in combination with genetic effects, influence onset and course of heavy drinking and alcohol problems, either directly, or through effects on timing of onset of alcohol use and on comorbid substance use, and effects on subsequent adult role changes of the twins (early or delayed parenting; relationship formation, conflict and dissolution; education completion, employment, and adult peer relationships); and to identify other variables (history of childhood or adolescent-onset psychopathology, other substance use disorders) that may mediate or moderate these relationships. Current understanding of the genetic epidemiology of female alcohol use disorders is based largely on either retrospective or underpowered studies - a gap that the MOAFTS cohort will help to fill.

我们提出了一波七个电话诊断访谈的随访（密苏里青少年） 女性双胞胎研究）年轻的队列A和B（目标n = 2100双访谈），对于某些参与者 尚未提供样品，唾液样本收集（目标n = 840）用于基因分型 确认。 Moafts是对女性类似性双胞胎对的出生队列的前瞻性研究（n = 370非洲 - 美国对，n = 1999年的欧洲/其他祖先对）从出生记录中确定，并首先评估 青春期中位数16岁。项目的目标是在广泛代表的一般情况下表征 人口雌性双胞胎队列，酒精中毒和相关物质的基因环境相互作用 疾病，重点关注（i）父母酒精中毒及其相关的双胞胎后代环境风险曝光 和结果，以及（ii）女性饮酒和与酒精有关的问题的发展和过程，以及 通过青春期进入其他物质使用和问题（尤其是烟草的使用和依赖性） 年轻成年，强调遗传和环境影响的前体/介体和主持人对 既有问题的发作又是恢复。在最近的数据收集中，访谈完成了 21-30岁的大约3500名受访者。第七波将进一步跟踪酒精和 其他物质使用和问题以及近端环境暴露，因此大多数双胞胎都通过 他们出现酒精问题的风险最大的时期，样本将足够大，可以提供信息 关于酒精问题和大量饮酒的缓解与持久性的预测因素（目标n = 700 在30岁时评估，n = 1400在28/n = 100个新依赖案例时评估）。我们的研究是有动力的 担心酒精和其他物质使用障碍的遗传传播 发生在通常与父母酒精中毒相关的高风险环境暴露的背景下 - 包括人际冲突和离婚或永不居民，继父母的存在，童年攻击 创伤，家庭社会经济劣势 - 不需要因酒精饮料而降低的风险 父母从家里。通过完成WAVE七个数据收集和数据 - 分析，我们的目标 要了解这些早期环境暴露如何与遗传作用结合 直接或通过对发作时间的影响，大量饮酒和酒精问题的发作和过程 饮酒和合并药物的使用以及对双胞胎的后续成人角色变化的影响 （早期或延迟育儿；建立关系，冲突和解散；教育完成，就业， 和成人的同伴关系）；并识别其他变量（儿童期或青少年的历史 精神病理学，其他物质使用障碍）可能会导致或调节这些关系。当前的 了解女性酒精使用障碍的遗传流行病学主要基于这两个 回顾性研究或能力不足的研究 - MoAfts队列将有助于填补的差距。