ALCOHOL USE DISORDER IN YOUNG WOMEN: GENETIC EPIDEMIOLOGY: MOAFTS WAVE 7

年轻女性酒精使用障碍：遗传流行病学：MOAFTS 第 7 波

• 批准号: 7730499
• 负责人: ANDREW C. HEATH
• 金额: $ 73.71万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7730499
• 关键词: 21 year old; Address; Adolescence; Adolescent; Adult; African American; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcoholism; Alcohols; Anxiety Disorders; Biological; Birth; Birth Records; Child; Childhood; Cohort Studies; Collection; Conflict (Psychology); Consent; Consumption; DNA; Data; Data Analyses; Data Collection; Deltastab; Dependence; Development; Diagnostic; Disadvantaged; Disease remission; Distal; Divorce; Education; Employment; Environment; Environmental Exposure; Environmental Risk Factor; Etiology; European; Failure; Family; Female; Female Adolescents; Forcible intercourse; Funding; General Population; Genes; Genetic; Genetic Determinism; Genetic Structures; Genetic Variation; Genotype; Goals; Grant; Heavy Drinking; Home environment; Hyperactive behavior; Impairment; Individual; Interview; Joints; Major Depressive Disorder; Marital Relationships; Marital separation; Marriage; Mediating; Mediator of activation protein; Missouri; Modeling; Molecular; National Institute of Child Health and Human Development; Oppositional Defiant Disorder; Outcome; Parenting behavior; Parents; Participant; Phenotype; Preparation; Preventive Intervention; Prospective Studies; Psychopathology; Recording of previous events; Recovery; Reporting; Reproduction; Research; Research Project Grants; Respondent; Risk; Role; Saliva; Sample Size; Sampling; Sexual abuse; Smoker; Smoking; Stepparent; Substance Use Disorder; Supervision; Surveys; Symptoms; Telephone; Testing; Time; Tobacco Dependence; Tobacco use; Trauma; Twin Multiple Birth; Twin Studies; Woman; alcohol misuse; alcohol related problem; alcohol risk; alcohol use disorder; base; cohort; college; consumption measures; depressive symptoms; drinking; follow-up; genetic epidemiology; high risk; inattention; informant; interpersonal conflict; offspring; peer; physical abuse; problem drinker; prospective; public health relevance; sample collection; sex; socioeconomics; transmission process; young adult

DESCRIPTION (provided by applicant): We propose a wave seven telephone diagnostic interview follow-up of the MOAFTS (Missouri Adolescent Female Twin Study) young cohorts A and B (target N=2100 twin interviews), and for some participants who have not yet provided samples, saliva sample collection (target N=840) for genotyping for zygosity confirmation. MOAFTS is a prospective study of a birth cohort of female like-sex twin pairs (N=370 African- American pairs, N=1999 European/Other Ancestry pairs) identified from birth records and first assessed in adolescence, at median age 16. Goals of the project are to characterize, in a broadly representative general population female twin cohort, gene-environment interplay in alcoholism and associated substance use disorders, focusing on (i) parental alcoholism and its associated twin offspring environmental risk-exposures and outcomes, and (ii) the development and course of female drinking and alcohol-related problems, as well as other substance use and problems (particularly tobacco use and dependence), through adolescence into young adulthood, emphasizing precursors/mediators and moderators of genetic and environmental effects on both onset of and recovery from problems. In the most recent data-collection, interviews were completed with approximately 3500 respondents at ages 21-30. Wave seven will provide a further follow-up of alcohol and other substance use and problems, and proximal environmental exposures, so that most twins are through their period of greatest risk for onset of alcohol problems, and the sample will be old enough to be informative about the predictors of remission versus persistence of alcohol problems and heavy drinking (target N=700 assessed at age 30, N=1400 assessed at age 28/N=100 new dependence cases). Our research is motivated by the concern that the genetic transmission of risks of alcohol and other substance use disorders frequently occurs in the context of high-risk environmental exposures commonly associated with parental alcoholism - including interpersonal conflict and divorce or never-cohabitation, step-parent presence, childhood assaultive trauma, family socioeconomic disadvantage - risks that need not be reduced by the departure of an alcoholic parent from the home. Through completion of the wave seven data-collection and data-analyses, our goals are to understand how these early environmental exposures, in combination with genetic effects, influence onset and course of heavy drinking and alcohol problems, either directly, or through effects on timing of onset of alcohol use and on comorbid substance use, and effects on subsequent adult role changes of the twins (early or delayed parenting; relationship formation, conflict and dissolution; education completion, employment, and adult peer relationships); and to identify other variables (history of childhood or adolescent-onset psychopathology, other substance use disorders) that may mediate or moderate these relationships. Current understanding of the genetic epidemiology of female alcohol use disorders is based largely on either retrospective or underpowered studies - a gap that the MOAFTS cohort will help to fill. PUBLIC HEALTH RELEVANCE: Alcohol misuse by young women is associated with significant impairments including difficulties in forming and maintaining stable romantic relationships, delayed reproduction, and impaired parenting, as well as risks associated with hazardous use. Better understanding of risk-mechanisms leading to the onset and persistence versus remission of female alcohol misuse in adolescence and young adulthood will have important implications for motivating and better targeting prevention and intervention efforts for young women and, in some cases, mitigating risks to their children.

描述（由申请人提供）：我们建议对 MOAFTS（密苏里州青少年女性双胞胎研究）年轻队列 A 和 B（目标 N=2100 双胞胎访谈）进行第七波电话诊断访谈随访，对于一些尚未提供样本的参与者，收集唾液样本（目标 N=840）用于基因分型以确认合子。 MOAFTS 是一项针对女性同性双胞胎出生队列（N = 370 对非裔美国人，N = 1999 对欧洲/其他血统对）的前瞻性研究，这些出生队列是从出生记录中确定的，并在青春期（中位年龄 16）进行首次评估。该项目的目标是在具有广泛代表性的一般人群女性双胞胎队列中描述酗酒和相关物质使用障碍中基因与环境的相互作用，重点关注 关于（i）父母酗酒及其相关双胞胎后代的环境风险暴露和后果，以及（ii）女性饮酒和酒精相关问题以及其他药物使用和问题（特别是烟草使用和依赖）的发展和进程，从青春期到成年早期，强调遗传和环境对问题发生和恢复的影响的先兆/中介和调节因素。在最近的数据收集中，对大约 3500 名 21 至 30 岁的受访者进行了采访。第七波将提供对酒精和其他物质使用和问题以及近端环境暴露的进一步跟踪，以便大多数双胞胎度过酒精问题发作的最大风险时期，并且样本年龄足够大，可以提供有关酒精问题和酗酒缓解与持续的预测因素的信息（目标 N=700 在 30 岁时评估，N=1400 在 28 岁时评估/N=100 个新的依赖病例）。我们的研究动机是担心酒精和其他物质使用障碍风险的遗传传播经常发生在通常与父母酗酒相关的高风险环境暴露的背景下——包括人际冲突和离婚或从未同居、继父母的存在、童年攻击性创伤、家庭社会经济劣势——这些风险不需要通过酗酒的父母离开家来减少。通过完成第七波数据收集和数据分析，我们的目标是了解这些早期环境暴露与遗传效应相结合，如何直接影响酗酒和酒精问题的发生和进程，或者通过对饮酒开始时间和共病物质使用的影响，以及对双胞胎随后成年角色变化的影响（早期或延迟养育；关系形成、冲突和解除；教育完成、就业和成年） 同伴关系）；并确定可能介导或缓和这些关系的其他变量（童年或青少年发病的精神病理学史、其他物质使用障碍）。目前对女性酒精使用障碍遗传流行病学的理解主要基于回顾性或动力不足的研究——MOAFTS 队列将有助于填补这一空白。公共卫生相关性：年轻女性滥用酒精会造成严重损害，包括难以形成和维持稳定的恋爱关系、延迟生育、养育子女受损，以及与危险使用相关的风险。更好地了解导致青春期和青年期女性酗酒发生、持续与缓解的风险机制，对于激励和更好地针对年轻女性进行预防和干预工作，以及在某些情况下减轻其子女面临的风险具有重要意义。