EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDY

描述：（改编自申请人的摘要） 痴呆症项目将Fragmentary研究的优势带到了 阿尔茨海默病的发病率、前兆和表现的研究 疾病（AD）和其他类型的痴呆症。 研究人员建议， 将本研究扩大到儿童（及其配偶）， 最初的Frakish队列谁是Frakish后代的成员 队列。 对后代AD和痴呆症的研究提出了一个独特的 有机会纵向检查和跟踪一个队列， 系统地评估神经系统， 建立了 父母双方的DNA样本 和后代群体和家庭关系的知识将 促进AD和痴呆症的遗传学研究。 此外，在过去40年的队列中， 后代，与AD和痴呆研究相关的风险因素数据 已系统地和常规地收集了所有主题的数据。 这些 包括：个人习惯、病史和家族史、心血管疾病 风险因素和记录的心血管事件以及卒中事件 这是一个相当详细的收集，在一个全面的 中风研究。许多血液化学测定已经完成 包括TSH，载脂蛋白，包括载脂蛋白E同种型， 同型半胱氨酸、叶酸和维生素B12。 从考试开始的认知能力下降研究 1976年，确定了AD和痴呆症的患病率和发病率。 受试者在家中、疗养院和慢性 医院以及Fraudal研究诊所。与推进的 年龄，特别是在中风或痴呆的存在下，增加 许多研究受试者将需要在其住所就诊。MRI 将对病例和对照组进行扫描，以确定缺血性变化 缺血性变化的数量、部位、大小和位置将被 与痴呆症以及神经系统和神经系统的特定模式有关， 使用标准MRI阅读方案的心理表现 由NHLBI的心血管健康研究开发。

DESCRIPTION: (Adapted from Applicant's Abstract) The Epidemiology of Dementia project brings the strengths of the Framingham Study to the study of the incidence, precursors and manifestations of Alzheimer's Disease (AD) and other types of dementia. The investigators propose to extend the present study to the children (and their spouses) of the original Framingham cohort who are members of the Framingham Offspring cohort. The investigation of AD and dementia in the offspring presents a unique opportunity to examine and follow longitudinally a cohort whose parents were systematically evaluated neurologically and whose dementia status was established. The availability of DNA samples for both the parents and offspring cohorts and knowledge of the family relationships will facilitate genetic studies of AD and dementia. In addition, during the past 40 years in the cohort, and 20 years in the offspring, risk factor data pertinent to the study of AD and dementia have been collected systematically and routinely on all subjects. These include: personal habits, medical and family history, cardiovascular risk factors and documented cardiovascular events, and stroke events which have been collected in considerable detail in a comprehensive stroke study.Many blood chemistry determinations have been made including TSH, apolipoproteins including the apo E isoforms, homocyst(e)ine, folate and vitamin B12. The study of cognitive decline in the Framingham Study which began on Exams in 1976, has determined the prevalence and incidence of AD and dementia. Subjects have been evaluated at home, in nursing homes and chronic hospitals as well as in the Framingham Study clinic. With advancing age, particularly in the presence of stroke or dementia, increasing numbers of study subjects will need to be seen at their residence. MRI scans will be performed on cases and controls to identify ischemic changes The number, site, size and location of the ischemic changes will be related to dementia and to specific patterns of neurologic and neuro- psychological performance using a standard MRI reading protocol developed by the Cardiovascular Health Study of the NHLBI.